DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and ALPG

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_112603.2	Gene:	ALPG / 251	HGNCID:	441	Length:	532	Species:	Homo sapiens

Alignment Length:	552	Identity:	235/552 - (42%)
Similarity:	305/552 - (55%)	Gaps:	59/552 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |.|:.:||:    ||..:.:..|::::  ..|..|:|:|||:|||||:||::|.||.||| .|..
Human    24 EEENPDFWN----RQAAEALGAAKKLQ--PAQTAAKNLIIFLGDGMGVSTVTAARILKGQ-KKDK 81

  Fly   115 YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG- 176
            .|.|..|..|.||...::|||:|||.||||..||||...|.|.::..||:.|..  ::.|..:|
Human    82 LGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGN 146

  Fly   177 RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQLV 239
            .|.|||..|:|.||..|||||||:.||:||..|||..:|:|..|.:|||.:  .|.. |||.||:
Human   147 EVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQ-DIATQLI 210

  Fly   240 ENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVP 301
            .|..   .:||||||   |.|||..: .|......:|.     ||.|.:||..||||.|..
Human   211 SNMD---IDVILGGGRKYMFPMGTPD-PEYPDDYSQGG-----TRLDGKNLVQEWLAKHQG---- 262

  Fly   302 PALVHNRKDLLNVNV-KKVDHLMGLFRNNHITYSIAREAG-EPSLQEMTETALGILERGDESNGF 364
            ...|.||.:||..:: ..|.||||||....:.|.|.|::. :|||.||||.||.:|.|  ...||
Human   263 ARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSR--NPRGF 325

  Fly   365 VLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRG 429
            .|.|||||||.|||.:.|..||.|...||.||:.|...|..::||.||||||||..:|.||.|||
Human   326 FLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRG 390

  Fly   430 ADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHL 494
            :.|.|.|.. :..|...|..:.|.|||||  .|.:.:||.           .|..|..:|.||..
Human   391 SSIFGLAPG-KARDRKAYTVLLYGNGPGY--VLKDGARPD-----------VTESESGSPEYRQQ 441

  Fly   495 ATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKDGQKD 559
            :.||...|||.||||||||.||.:.|:.||.||.::|:||::|.||.|....|.:       .:.
Human   442 SAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLA-------PRA 499

  Fly   560 RPLDKPNPKRNGATVVGASLIPILTAATAAIL 591
            ...|..:|   |.:||.| |:|:| |.|..:|
Human   500 GTTDAAHP---GPSVVPA-LLPLL-AGTLLLL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	212/483 (44%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	211/465 (45%)
ALPG	NP_112603.2	PRK10518	25..475	CDD:236706	213/486 (44%)
		Alk_phosphatase	52..487	CDD:278666	211/465 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660