Protein Alignment Alp4 and ALPL

DIOPT Version :9

• Sequence 1: NP_524601.2
• Gene: Alp4 / 43671
• FlyBaseID: FBgn0016123
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 210/503 - (41%)
• Similarity: 290/503 - (57%)
• Gaps: 42/503 - (8%)

  Fly    49 KEPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKH 113
            ::.:|.::|.:    |.::|:|.|..:::.: ...|:|:|:|:|||||:||::|.||.||| |.|
Human    21 EKEKDPKYWRD----QAQETLKYALELQKLN-TNVAKNVIMFLGDGMGVSTVTAARILKGQ-LHH 79

  Fly   114 GYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDAT--RSKKNGQQG 176
            ..|||..|..|.||...::||||.:.|||||||||||...|.|.:.|.:|:.|.  ||:.|..||
Human    80 NPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQG 144

  Fly   177 -RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGFHV-DIARQLV 239
             .|.|::.||:..||..|:|||||:.||||:|.|||..||||..|.|:|.|::.... |||.||:
Human   145 NEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLM 209

  Fly   240 ENAPGNRFNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLA-----HHANDT 299
            .|.  ...:||:|||...|...|.::|:   :|...:...||.|..:|...|.:     .|::
Human   210 HNI--RDIDVIMGGGRKYMYPKNKTDVE---YESDEKARGTRLDGLDLVDTWKSFKPRYKHSH-- 267

  Fly   300 VPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAR-EAGEPSLQEMTETALGILERGDESNG 363
                .:.||.:||.::...||:|:|||....:.|.:.| ...:|||.||...|:.||.:..:  |
Human   268 ----FIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPK--G 326

  Fly   364 FVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALR 428
            |.|||||||||.|||...|:.||||..|.|.||..|.:.|..::||.:|||||||..||.||..|
Human   327 FFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPR 391

  Fly   429 GADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRH 493
            |..|.|.|......|...:..|.|.|||||  .:....| :|.|.:          :.|...|:.
Human   392 GNSIFGLAPMLSDTDKKPFTAILYGNGPGY--KVVGGER-ENVSMV----------DYAHNNYQA 443

  Fly   494 LATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLG 541
            .:.||.:.|||||||||||:.||.:.|:.||.||||:.:||:||.|:|
Human   444 QSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIG 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	202/483 (42%)
		alkPPc	85..541	CDD:214515	202/465 (43%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:333956	202/465 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660