Protein Alignment Alp4 and ALPI

DIOPT Version :9

• Sequence 1: NP_524601.2
• Gene: Alp4 / 43671
• FlyBaseID: FBgn0016123
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 238/557 - (42%)
• Similarity: 308/557 - (55%)
• Gaps: 73/557 - (13%)

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |.|:..||:    ||..:.:..|::::  ..||.|:|:|:|:|||:|:.|::|.||.|||  |:|
Human    24 EEENPAFWN----RQAAEALDAAKKLQ--PIQKVAKNLILFLGDGLGVPTVTATRILKGQ--KNG 80

  Fly   115 -YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG 176
             .|.|..|..|.||...::||||||:||||||.||||...|.|.::..||:.|..  ::.|..:|
Human    81 KLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRG 145

  Fly   177 -RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQL 238
             .|.|||..|::.||..|||||||:.||:||.||||..:|:|..|.::||.:  .|.. |||.||
Human   146 NEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQ-DIATQL 209

  Fly   239 VENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTETICT--RGDNRNLPAEWLAHHAND 298
            :.|..   .:||||||   |.|||        |...|.|.:....  |.|.:||..||||.|..
Human   210 ISNMD---IDVILGGGRKYMFPMG--------TPDPEYPADASQNGIRLDGKNLVQEWLAKHQG- 262

  Fly   299 TVPPALVHNRKDLLNVNV-KKVDHLMGLFRNNHITYSIAREAG-EPSLQEMTETALGILERGDES 361
               ...|.||.:|:..:: :.|.||||||......|.|.|:.. :|||.||||.||.:|.|  ..
Human   263 ---AWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSR--NP 322

  Fly   362 NGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYA 426
            .||.|.|||||||.|||...|..||.|...||.||:.|...|..::||.||||||||..:|.||.
Human   323 RGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYT 387

  Fly   427 LRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDS-RPQ-NSSNMWMPLKHFTAEERAAP 489
            |||:.|.|.|.| :..|...|.:|.|.|||||   :.|.. ||. |.|            |..:|
Human   388 LRGSSIFGLAPS-KAQDSKAYTSILYGNGPGY---VFNSGVRPDVNES------------ESGSP 436

  Fly   490 TYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHK 554
            .|:..|.||...||||||||||||.||.:.|:.||.||:::|:||::|.||.|.    .:|:
Human   437 DYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY----TACD--- 494

  Fly   555 DGQKDRPLDKPNPKRNGATVVGASLIPILTAATAAIL 591
                   |..|....:.|..|.||| |:| |.|..:|
Human   495 -------LAPPACTTDAAHPVAASL-PLL-AGTLLLL 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	215/488 (44%)
		alkPPc	85..541	CDD:214515	213/470 (45%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	213/470 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660