DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp4 and AgaP_AGAP010596

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_314561.4	Gene:	AgaP_AGAP010596 / 1275323	VectorBaseID:	AGAP010596	Length:	574	Species:	Anopheles gambiae

Alignment Length:	557	Identity:	276/557 - (49%)
Similarity:	357/557 - (64%)	Gaps:	26/557 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VGKTKEPEDAEFWHNVGLRQLEKTIKQAQRVKED--SYQKKARNIIIFIGDGMGISTISAGRIYK 107
            |.|:...:||.||.    |..|..:|:.....|:  .....|:|||||:||||||:::|.|||:|
Mosquito    36 VYKSPNLDDARFWR----RNAETYLKKVLMYDENRRMIPSVAKNIIIFVGDGMGIASLSTGRIFK 96

  Fly   108 GQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKN 172
            ||..... ||||.|.||:||||||:||||.|:|||||||||||:|||.||.||.:|:|.|.::.|
Mosquito    97 GQRAGRS-GEEEQLSFDNFPNTGMSKTYNTDRQVPDSAGTATAMFSGVKTKYGVLGVDYTITETN 160

  Fly   173 GQQGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGFHVDIARQ 237
            .:..::.|.|:|||:||||||:|||||:|||||||.|||..:|::||..::|........|||||
Mosquito   161 LEAAKLPSFMDWAQEEGKRTGIVTTTRVTHATPAACYAHSINRNYECGAKIPVHLKNRIKDIARQ 225

  Fly   238 LVENAPGNRFNVILGGGMSPMGILNASEVKTTI-FEGPTETICTRGDNRNLPAEWLAHHANDTVP 301
            ::|:|||...||:||||.:..|....:.:|... |:|..|..|.|.|.|||..||.... |.| .
Mosquito   226 MMEDAPGKNLNVVLGGGRNHFGASMPNHLKPEYQFQGAMEKTCMRTDGRNLVEEWKLRW-NGT-N 288

  Fly   302 PALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAREA---GEPSLQEMTETALGILERGDESNG 363
            .|......||..|.:.|||||:|||.::|::|...|:.   |||||.||||.|:.:|:|.| |.|
Mosquito   289 AAYAWKTSDLRAVELDKVDHLLGLFNDDHLSYDTVRDRTPDGEPSLSEMTEAAIKVLQRPD-SAG 352

  Fly   364 FVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALR 428
            |.|:|||||||..||.|:|..||.|:.|.|.|::.|:...|.|||||:||||||||:|||||..|
Mosquito   353 FALMVEGGRIDHAHHQNHAHLALAEVVELDKAVETALKLVDLDETLIIVTADHSHAMTFNGYPDR 417

  Fly   429 GADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRH 493
            |.||||..|   :.:...||||:||||||:..|..|.|.....|..|..........|:..||:|
Mosquito   418 GNDILGFGN---RPNATPYETITYANGPGFLQHRWNSSLLSEESTDWATWIKLNQLNRSEVTYKH 479

  Fly   494 LATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKDGQK 558
            |:..|..|||||||||||||.|||::|:||.|||||:|||||||||:||||.|:.:|:|
Mosquito   480 LSAFPLPDETHGGEDVAVFASGPGANLVRGTFEQNYIAYVMSYAGCMGPAKRFNLACDD------ 538

  Fly   559 DRPLDKPNPKRNGATVVGASLIPILTAATAAI-LRGR 594
            |.|  :...|.:||....:|::.::.:..|.: |.||
Mosquito   539 DFP--RTAAKASGAQRAVSSIVLVIASLHAMVSLVGR 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	246/479 (51%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	248/459 (54%)
AgaP_AGAP010596	XP_314561.4	alkPPc	74..527	CDD:214515	248/459 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	475	1.000	Domainoid score	I1423
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H122414
Inparanoid	1	1.050	498	1.000	Inparanoid score	I3062
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		oto111051
Panther	1	1.100	-	-	LDO	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	1	0.960	-	-
	13	12.940