DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp4 and Akp3

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	566	Identity:	235/566 - (41%)
Similarity:	301/566 - (53%)	Gaps:	64/566 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |.|:..||:......|: ..|:.|.:     |..|:|:|||:|||||:.|::|.||.|||...|
Mouse    24 EEENPAFWNKKAAEALD-AAKKLQPI-----QTSAKNLIIFLGDGMGVPTVTATRILKGQLEGH- 81

  Fly   115 YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG- 176
            .|.|..|..|.||...::|||:||:||||||.||||...|.||:|..||:.|..  .:.|...|
Mouse    82 LGPETPLAMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGN 146

  Fly   177 RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESV--GFHVDIARQLV 239
            .|.|||..|:|.||..|||||||:.||:|:.||.|..:|:|..|.::||.::  |.. |||.||:
Mouse   147 EVFSVMYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWYGDADMPASALREGCK-DIATQLI 210

  Fly   240 ENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTET--ICTRGDNRNLPAEWLAHHANDT 299
            .|..   .|||||||   |.|.|        |...|.|.:.  ..||.|.|||..|||:.|...
Mouse   211 SNMD---INVILGGGRKYMFPAG--------TPDPEYPNDANETGTRLDGRNLVQEWLSKHQGS- 263

  Fly   300 VPPALVHNRKDLL-NVNVKKVDHLMGLFRNNHITYSIARE-AGEPSLQEMTETALGILERGDESN 362
               ..|.||:.|: ......|.:|||||......:.|.|: ..:|||::|||.|:.:|.|..:
Mouse   264 ---QYVWNREQLIQKAQDPSVTYLMGLFEPVDTKFDIQRDPLMDPSLKDMTEAAVKVLSRNPK-- 323

  Fly   363 GFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYAL 427
            ||.|.|||||||:|||:..|..||.|...|||||:.|...|...:||.:|||||||..:|.||.|
Mouse   324 GFYLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHSHVFSFGGYTL 388

  Fly   428 RGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYR 492
            ||..|.|.|..:.. |...|.:|.|.|||||   :....||           :.||.|.:..:||
Mouse   389 RGTSIFGLAPLNAL-DGKPYTSILYGNGPGY---VGTGERP-----------NVTAAESSGSSYR 438

  Fly   493 HLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKD------FDDSCE 551
            ..|.||.|.|||||||||:||.||.:.|:.||.||||:|:||::||||.|..|      .|:|..
Mouse   439 QQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADESQT 503

  Fly   552 DHKDGQ------KDRPLDKPNPKRNGATVVGASLIPILTAATAAIL 591
            .....|      .........|..|.|..:|.:..|:..|..|.:|
Mouse   504 TTTTRQTTITTTTTTTTTTTTPVHNSARSLGPATAPLALALLAGML 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	212/485 (44%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	212/467 (45%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	212/467 (45%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531		5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660