DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and alpl

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_031762314.1	Gene:	alpl / 100485467	XenbaseID:	XB-GENE-1010301	Length:	527	Species:	Xenopus tropicalis

Alignment Length:	562	Identity:	234/562 - (41%)
Similarity:	316/562 - (56%)	Gaps:	54/562 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LIRTLSAGGDIGPQFDVGKTKEPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGD 93
            |:.|||.        .|...::.:|.::|.    ||.:.|::.|..:.::.....|:|:|:|:||
Frog     9 LLGTLSE--------SVTFPEQEKDPKYWR----RQAQDTLRDALLLLQNLNTNVAKNVIMFLGD 61

  Fly    94 GMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTH 158
            |||:.|::|.||.||| :....|||..|..|.||:..::||||.:.|||||||||||...|.|.:
Frog    62 GMGVPTVTATRILKGQ-MAGQPGEETQLEMDKFPHVALSKTYNTNAQVPDSAGTATAYLCGVKAN 125

  Fly   159 YGAIGMD--ATRSKKNGQQG-RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECD 220
            .|.:|::  |.|.:.|..:| .|.|:::||::.||..||||||||.||||:|.|||..:|||..|
Frog   126 EGTVGVNAAAVRGQCNTTRGNEVDSILKWAKQAGKSVGVVTTTRINHATPSAAYAHCVNRDWYSD 190

  Fly   221 TEVPAESV--GFHVDIARQLVENAPGNRFNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGD 283
            .|:|.|:|  |.. |||.||:.|.|  ...||:|||...|...|.|:|:   :....:...||.|
Frog   191 LEMPKEAVEQGCK-DIAWQLMHNVP--NIEVIMGGGRKYMYPRNTSDVE---YPNDDKASGTRLD 249

  Fly   284 NRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAREAG-EPSLQEM 347
            ..||...||....|... ...|.||:.||:||.::||||:|||....:.|.:.|... :|||.||
Frog   250 GLNLTQIWLDQKPNKQA-ARYVWNRQQLLSVNPQEVDHLLGLFEPIDMLYELERNTTMDPSLPEM 313

  Fly   348 TETALGILERGDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILV 412
            .|.|:.||.:..|  ||.|||||||||.|||...|..||||..:.|:||..|.:.|..::||.:|
Frog   314 VEMAIKILRKNPE--GFFLLVEGGRIDHGHHEGKANQALHEAVQMDIAIGLAGSMTSEEDTLTVV 376

  Fly   413 TADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMP 477
            ||||||..||.||..||..|.|.|.:....|...:.:|.|.|||||  .|.|..| :|.|.:
Frog   377 TADHSHVFTFGGYTHRGTSIFGLAPAVSDVDQKPFTSILYGNGPGY--KLVNGQR-ENVSTV--- 435

  Fly   478 LKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGP 542
                   :.:.|.|...:.||.:.||||||||||||.||.:.|:.||.||||:.:||:||.|:|.
Frog   436 -------DFSHPNYLAQSAVPLRMETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGQ 493

  Fly   543 AKDFDDSCEDHKDGQKDRPLDKPNPKRNGATVVGASLIPILT 584
            .:   |.|...|:..         ..|...|:|.| |:|:|:
Frog   494 NQ---DHCTSGKESY---------GARTSLTLVSA-LLPLLS 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	211/479 (44%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	211/461 (46%)
alpl	XP_031762314.1	Alk_phosphatase	52..491	CDD:395188	211/461 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930