DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and Alpp

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	225/508 - (44%)
Similarity:	281/508 - (55%)	Gaps:	51/508 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |.|:..||:......|| ..|:.|.:     |..|.|:||.:|||||:||::|.||.|||...|
  Rat    23 EEENPAFWNRKAAEALE-AAKKLQPI-----QTSANNLIILMGDGMGVSTVTATRILKGQQQGH- 80

  Fly   115 YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG- 176
            .|.|..|..|.||:..::||||.||||||||||.||...|.||:...||:.|..  ::.|...|
  Rat    81 LGPETPLAMDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTWGN 145

  Fly   177 RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESV--GFHVDIARQLV 239
            .|.|||..|:|.||..||||||.:.||:||.||||..:|:|..|..:...::  |.. |||.||:
  Rat   146 EVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAHMSTAALQEGCK-DIAMQLI 209

  Fly   240 ENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPT--ETICTRGDNRNLPAEWLAHHANDT 299
            .|..   .:||||||   |.|.|        |...|.||  :...||.|.|||..||||.|..
  Rat   210 SNTD---IDVILGGGRKFMFPKG--------TPDQEYPTDPQQAGTRLDGRNLVQEWLAKHQG-- 261

  Fly   300 VPPALVHNRKDLLNVNV-KKVDHLMGLFRNNHITYSIARE-AGEPSLQEMTETALGILERGDESN 362
              ...|.||.:|:..:: :.|.||||||..|.:.|:|.|: ..:|||.||||.|:.:|.|..:
  Rat   262 --AQYVWNRTELIQASLNRSVTHLMGLFEPNDMKYNIDRDPTQDPSLAEMTEVAVHMLSRNPK-- 322

  Fly   363 GFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYAL 427
            ||.|.|||||||.|||...|..||.|...||.|:..|...|...:|:|:|||||||..:|.||..
  Rat   323 GFYLFVEGGRIDHGHHEAIAYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGYTQ 387

  Fly   428 RGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYR 492
            |.|.|.|.| ..:..|...:.:|.|.|||||  .|.|..|..           .|.||.:.|||:
  Rat   388 REASIFGLA-PFKAGDGKSFTSILYGNGPGY--KLNNGIRAD-----------VTEEESSNPTYQ 438

  Fly   493 HLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKD 545
            ..|.||...|||.|||||:||.||.:.|:.||.||||:|:||::||||.|..|
  Rat   439 QQAAVPLSSETHSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTD 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	213/485 (44%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	212/467 (45%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	212/467 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760