DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and alp3

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	545	Identity:	219/545 - (40%)
Similarity:	295/545 - (54%)	Gaps:	75/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKK-----ARNIIIFIGDGMGISTISAGRIYKGQ 109
            |.|:.|||.           |.||.....:..:|     |:||::|:|||||::||:|.||.|||
Zfish    21 EEENPEFWR-----------KSAQNTLRSALSRKINTNVAKNIVLFLGDGMGVTTITAARILKGQ 74

  Fly   110 YLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNG- 173
            ..||. |||..:..|.|||.|:||.|:||.|:||||.||||...|.||:...:|:.|  :.:||
Zfish    75 LQKHS-GEETVMNMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSA--AARNGV 136

  Fly   174 ---QQG-RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESV--GFHV 232
               |:| .|.|::.||:..||..|:|||||:.||||||::||...|.|..|.::||.:.  |. |
Zfish   137 CRSQKGNEVTSILRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADLPASAATEGC-V 200

  Fly   233 DIARQLVENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAH 294
            |||.||:.|..   .:||:|||   |:|.|..:.........:|      .|.|.|||..:|:
Zfish   201 DIATQLLHNID---IDVIIGGGRKYMTPKGFPDPEYPSDASAQG------QRRDGRNLIQDWI-- 254

  Fly   295 HANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIARE-AGEPSLQEMTETALGILERG 358
            ...:......|.|:.|...|:.:|.|:||.||....:.:.:.|: :.:||:.|.|:.|:.||::.
Zfish   255 QMKEGKVARYVWNKTDFDAVDPEKTDYLMALFEPADLRFDVERDHSMDPSISETTDKAIQILKKN 319

  Fly   359 DESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFN 423
            .:  ||.|||||||||||||.:.|.|||||....|.|:...:..||.:|||.:||||||||.|||
Zfish   320 PK--GFFLLVEGGRIDQGHHSSRASAALHEAVALDEAVSRGLELTDEEETLTIVTADHSHAFTFN 382

  Fly   424 GYALRGADILGTANSHEKNDPMF------YETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFT 482
            ||..||..|||       ..|:|      |.|:.|.||||:  .:.|:.||.           ..
Zfish   383 GYPFRGNSILG-------KSPIFASDFLPYTTLMYGNGPGH--KITNNKRPD-----------IR 427

  Fly   483 AEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFD 547
            ..:.|...|...:.||...||||||||||||.||.:.|.:||:||||:.:.|:||.|:|   :..
Zfish   428 KVDTADKDYIQQSAVPLDSETHGGEDVAVFARGPMAHLFQGVYEQNYIPHAMAYAACIG---ENQ 489

  Fly   548 DSC--EDHKDGQKDRPLDKPNPKRN 570
            ..|  ....|...|...|..|..:|
Zfish   490 QHCAITAKPDENPDTSTDPGNSAQN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	203/495 (41%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	202/472 (43%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	204/488 (42%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	202/472 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760