DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and alpi.2

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001116946.1	Gene:	alpi.2 / 100144722	XenbaseID:	XB-GENE-854953	Length:	532	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	212/563 - (37%)
Similarity:	290/563 - (51%)	Gaps:	83/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VGKTKEPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQ 109
            |...:..::.:||::    |.::|:|.|..:...::  :|:|:|:|:|||||::||:|.|||:||
Frog    33 VSSLEAEKNPKFWND----QAKETLKNALNLNPITH--RAKNLIMFLGDGMGVTTIAAARIYQGQ 91

  Fly   110 YLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDA-------T 167
             ::...|||..:..:.||...::|.||||.||||||||.||...|.|.:.|.:|:.|       .
Frog    92 -VEGQPGEENIMAMEKFPYVALSKVYNVDAQVPDSAGTGTAYLCGVKANSGTLGVSAAAIYGNCV 155

  Fly   168 RSKKNGQQGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGFHV 232
            .||.|    .|.|::..|:..||..|:|||||:.||:|.|.|||...|:|..|.|:.:..:....
Frog   156 SSKGN----EVTSILHRAKLAGKSVGIVTTTRVQHASPGAAYAHSASRNWYSDNEMTSAMINNGC 216

  Fly   233 -DIARQLVENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLA 293
             |||.|||.|..   .:||||||   |.|.|..:..      :.|.:.....|.|..||...||:
Frog   217 KDIAYQLVHNTD---IDVILGGGRAYMYPAGTPDPE------YPGSSADRGLRRDGLNLTDIWLS 272

  Fly   294 HHANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAREAG-EPSLQEMTETALGILER 357
            ...|    ...|.|::....|||...|:|||||....:.|.:.|.|. :|||.||||.|:.||.:
Frog   273 KRQN----ARYVWNKEQFNAVNVDTTDYLMGLFEPKDMKYELNRNASLDPSLAEMTEKAIRILSK 333

  Fly   358 GDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTF 422
            ..:  ||.|.|||||||.|||...|:.:|.|..|||.|:......|..:|||.:|||||||..||
Frog   334 NPK--GFFLFVEGGRIDHGHHDGNAKQSLTEALEFDKAVLRGGQLTQENETLTVVTADHSHVFTF 396

  Fly   423 NGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPL-----KHFT 482
            .||..||..|.|.|.| ..:|...|.::.|.|||||                  ||     .:.|
Frog   397 GGYTDRGNSIFGLAPS-LASDRKPYTSLLYGNGPGY------------------PLPDAIRANIT 442

  Fly   483 AEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFD 547
            .....:.:|...|.||...|||||||||:.|.||.:.|..|..||:|:|:||:||.||.|..:
Frog   443 GVNTGSNSYLQQAAVPVVSETHGGEDVAIMAKGPQAHLFHGFHEQSYIAHVMAYAACLEPYTE-- 505

  Fly   548 DSCEDHKDGQKDRPLDKPNPKRNGATVVGASLIPILTAATAAI 590
              |..                 ||.::..|:::|:|||....|
Frog   506 --CPP-----------------NGGSIYTATILPLLTACLVCI 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	193/490 (39%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	193/472 (41%)
alpi.2	NP_001116946.1	Alk_phosphatase	66..500	CDD:333956	193/472 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010