DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and CMP2

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_013655.1	Gene:	CMP2 / 854946	SGDID:	S000004521	Length:	604	Species:	Saccharomyces cerevisiae

Alignment Length:	596	Identity:	295/596 - (49%)
Similarity:	383/596 - (64%)	Gaps:	75/596 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSATSTRSS---------VTRKSSLSKSSSSDKSAKSSSNSSKSPTAASGNKQKMQYT------- 49
            ||:.:.|::         :..|:...:||::...:|:|:.::.:.||...::...|||
Yeast     1 MSSDAIRNTEQINAAIKIIENKTERPQSSTTPIDSKASTVAAANSTATETSRDLTQYTLDDGRVV 65

  Fly    50 KTRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLRE 114
            .|..|:::.||...:|..|..|::.  ..|.|..:.||.||..||::..|.|.||:|....|..:
Yeast    66 STNRRIMNKVPAITSHVPTDEELFQ--PNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSK 128

  Fly   115 EKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKIT 179
            |.|:|.|.||||||||||||:|||:|||||||.||||.|||||||||||.||.||::||:|||:.
Yeast   129 EPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLN 193

  Fly   180 YPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSP 244
            :.....||||||||:|||.|||||.|.:.||:..||:.|.|:|:.||||||:|.|:||:|||:||
Yeast   194 FNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISP 258

  Fly   245 EIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFG-------------NEKT-----------N 285
            |:.:|.||..||||||.|::|.||||||:||:|::.             |.||           .
Yeast   259 ELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEVLDKDLTEEDIVNSKTMVPHHGKMAPSR 323

  Fly   286 EFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPN 350
            :.|..||||||||.|:|.|.|.|||:..||||:|||||||||||||:..:..|||||:|:|||||
Yeast   324 DMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKTLGFPSLLTLFSAPN 388

  Fly   351 YLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDD 415
            |||.||||||:||||||||||||||.:|||||||:|||||||||||||||||||||.|||||::|
Yeast   389 YLDTYNNKAAILKYENNVMNIRQFNMTPHPYWLPDFMDVFTWSLPFVGEKVTEMLVAILNICTED 453

  Fly   416 EL---------VAGPDDELEEELRKKIVLVPANASNNNNNNNTPSKPASMSAL----RKEIIRNK 467
            ||         :.|.|.:|.:..:.:....||          |.:.|...|.|    |::.:|||
Yeast   454 ELENDTPVIEELVGTDKKLPQAGKSEATPQPA----------TSASPKHASILDDEHRRKALRNK 508

  Fly   468 IRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEALQGLTASSHIHSFAEAK 532
            |.|:.|:||::|:||||:..|..||... :|.||.||||.|...|.|||.         :|..|:
Yeast   509 ILAVAKVSRMYSVLREETNKVQFLKDHN-SGVLPRGALSNGVKGLDEALS---------TFERAR 563

  Fly   533 GLDAVNERMPP 543
            ..|.:||::||
Yeast   564 KHDLINEKLPP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	199/327 (61%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	178/294 (61%)
CMP2	NP_013655.1	MPP_PP2B	95..423	CDD:277361	199/327 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I262
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56429
Inparanoid	1	1.050	546	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0.740582	Normalized mean entropy	S271
OMA	1	1.010	-	-		QHG53795
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm9223
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
TreeFam	1	0.960	-	-
	14	13.780