DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and CNA1

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_013537.1	Gene:	CNA1 / 851153	SGDID:	S000004425	Length:	553	Species:	Saccharomyces cerevisiae

Alignment Length:	545	Identity:	285/545 - (52%)
Similarity:	376/545 - (68%)	Gaps:	35/545 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSK--SSSSDKSAKSSSNSSKSPTAASGNKQKMQYTK---TRERMVDDVPLPPTHKLTMSEVYDD 75
            :||  :||..|..|.:.:..|........|.:::..|   |::|.:..|| ..|.|:...|...|
Yeast     1 MSKDLNSSRIKIIKPNDSYIKVDRKKDLTKYELENGKVISTKDRPIASVP-AITGKIPSDEEVFD 64

  Fly    76 PKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVK 140
            .|||.||...||:||..|||:.:..|::|:......|.:|.|::.::||||:|||||||::||:|
Yeast    65 SKTGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLK 129

  Fly   141 LFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQE 205
            ||||||.||...|||||||||||.||.||::||:|||:.......:|||||||:|||.|||||.|
Yeast   130 LFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNE 194

  Fly   206 CIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDL 270
            .:.||...:||||..:|:.||||||:|.|:.|:|||:|||:.:::|:..:|||||.|:.|.||||
Yeast   195 MLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDL 259

  Fly   271 LWSDPLEDF-----GNE--KTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGY 328
            ||:||:|::     |:|  ::.:.|..||:||||:.|::.|.|:||:.|.||||:||||||||||
Yeast   260 LWADPVENYDDARDGSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGY 324

  Fly   329 RMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWS 393
            |||:.|:|||||||||:||||||||.|:|||||||||.||||||||:.||||||||:||||||||
Yeast   325 RMYKNNKVTGFPSLITMFSAPNYLDTYHNKAAVLKYEENVMNIRQFHMSPHPYWLPDFMDVFTWS 389

  Fly   394 LPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASNNNNNNNTPSKPASMSA 458
            |||||||||.|||:||||||:.||    |.|.|.:..::.|...|||:   ....|||...:.||
Yeast   390 LPFVGEKVTSMLVSILNICSEQEL----DPESEPKAAEETVKARANAT---KETGTPSDEKASSA 447

  Fly   459 L-----RKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEALQG 518
            :     |::.:||||.||.|:||:||:||||||.|..||.:. .|.||.|||:.|.:.|.|.|.
Yeast   448 ILEDETRRKALRNKILAIAKVSRMFSVLREESEKVEYLKTMN-AGVLPRGALARGTEGLNETLS- 510

  Fly   519 LTASSHIHSFAEAKGLDAVNERMPP 543
                    :|.:|:..|.:||::||
Yeast   511 --------TFEKARKEDLINEKLPP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	186/310 (60%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	163/277 (59%)
CNA1	NP_013537.1	MPP_PP2B	70..381	CDD:277361	186/310 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I262
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	546	1.000	Inparanoid score	I170
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm9223
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
TreeFam	1	0.960	-	-
	12	11.830