DRSC/TRiP Functional Genomics Resources

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Protein Alignment CanA1 and PPP3CC

DIOPT Version :9

Sequence 1:NP_001247378.2 Gene:CanA1 / 43670 FlyBaseID:FBgn0010015 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001230903.1 Gene:PPP3CC / 5533 HGNCID:9316 Length:521 Species:Homo sapiens


Alignment Length:541 Identity:365/541 - (67%)
Similarity:431/541 - (79%) Gaps:36/541 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 YTKTRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALL 112
            :..|.:|::..||.|||.:||..||:::   |||..|.|:.|.:.|||:||.|||:||.:|||:|
Human     7 HLSTTDRVIKAVPFPPTQRLTFKEVFEN---GKPKVDVLKNHLVKEGRLEEEVALKIINDGAAIL 68

  Fly   113 REEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLK 177
            |:||.||:|:||||||||||||||||:|||||||.|:.|||||||||||||||||||||||||||
Human    69 RQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLK 133

  Fly   178 ITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGL 242
            |.:|.||.||||||||||||:||||||||.|||||.:||||||.||||||||||||||||:|||:
Human   134 INHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGM 198

  Fly   243 SPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCE 307
            ||||.:||||:.|:||.||||:||:||||||||.||:|||||.|.::||:|||||||:||.|.||
Human   199 SPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCE 263

  Fly   308 FLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIR 372
            |||.||||||:|||||||||||||||:|.||||||||||||||||||||||||||||||||||||
Human   264 FLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIR 328

  Fly   373 QFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVP 437
            |||||||||||||||||||||||||||||||||||:|||||||||::  |||.|:          
Human   329 QFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELIS--DDEAED---------- 381

  Fly   438 ANASNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPV 502
                     :..||.....:.:|||||||||||||||:|||||||:||||||.||||||||.||:
Human   382 ---------HYIPSYQKGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPL 437

  Fly   503 GALSGGRDSL----------KEALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSIT 557
            |.||||:.::          :||::|.:....|.||.||:|||.:|||||||:..:  .:...:.
Human   438 GVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSI--HAGGPMK 500

  Fly   558 TVTRSSSSSSNNNNNNSNTSS 578
            :||.:.|.:::.::......|
Human   501 SVTSAHSHAAHRSDQGKKAHS 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CanA1NP_001247378.2 MPP_PP2B 81..385 CDD:277361 248/303 (82%)
PP2Ac 98..369 CDD:197547 224/270 (83%)
PPP3CCNP_001230903.1 MPP_PP2B 37..341 CDD:277361 248/303 (82%)
Catalytic. /evidence=ECO:0000305 52..343 243/290 (84%)
PP2Ac 54..325 CDD:197547 224/270 (83%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 303..307 3/3 (100%)
Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298 344..366 20/21 (95%)
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298 395..409 13/13 (100%)
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 410..417 5/6 (83%)
Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298 468..490 14/21 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 480..521 11/42 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142538
Domainoid 1 1.000 89 1.000 Domainoid score I7827
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 1 1.010 - - D194337at33208
OrthoFinder 1 1.000 - - FOG0000983
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100566
Panther 1 1.100 - - O PTHR45673
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X576
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.720

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