DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and PPP3CA

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_000935.1	Gene:	PPP3CA / 5530	HGNCID:	9314	Length:	521	Species:	Homo sapiens

Alignment Length:	538	Identity:	374/538 - (69%)
Similarity:	436/538 - (81%)	Gaps:	42/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREE 115
            |.:|:|..||.||:|:||..||:|:  .|||..|.|:.|.:.|||:||:||||||||||::||:|
Human    13 TTDRVVKAVPFPPSHRLTAKEVFDN--DGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQE 75

  Fly   116 KNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITY 180
            ||::|::||:|||||||||||||:|||||||.||.||||||||||||||||||||||||:|||.|
Human    76 KNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILY 140

  Fly   181 PTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPE 245
            |.||.|||||||||||||||||||||.|||||.:|||||:||||||||||:||||||:|||||||
Human   141 PKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPE 205

  Fly   246 IFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310
            |.|||||:.|:||:||||||||||:||||||||||||||.|.|:||:|||||||:||.|.|||||
Human   206 INTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQ 270

  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 375
            .||||||:|||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
Human   271 HNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 335

  Fly   376 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANA 440
            ||||||||||||||||||||||||||||||||:|||||||||  |.:::
Human   336 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--GSEED---------------- 382

  Fly   441 SNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGAL 505
                      ....:.:|.|||:|||||||||||:||||:|||||||||.||||||||.||.|.|
Human   383 ----------GFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVL 437

  Fly   506 SGGRDSLK----------EALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVT 560
            |||:.:|:          ||::|.:....|.||.||||||.:||||||||..:  .|.:::.::.
Human   438 SGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM--PSDANLNSIN 500

  Fly   561 RSSSSSSNNNNNNSNTSS 578
            ::.:|.:|..::|.:.||
Human   501 KALTSETNGTDSNGSNSS 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	255/303 (84%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	231/270 (86%)
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	255/303 (84%)
		Catalytic. /evidence=ECO:0000305	56..340		243/283 (86%)
		SAPNY motif. /evidence=ECO:0000305\|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:18384083, ECO:0000269\|PubMed:19404396, ECO:0000269\|PubMed:25144868, ECO:0000269\|Ref.31	392..406		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414		4/6 (67%)
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:8524402	465..487		15/21 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521		17/46 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7827
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.740582	Normalized mean entropy	S271
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740