DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and PPEF2

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_006230.2	Gene:	PPEF2 / 5470	HGNCID:	9244	Length:	753	Species:	Homo sapiens

Alignment Length:	635	Identity:	138/635 - (21%)
Similarity:	216/635 - (34%)	Gaps:	225/635 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TRERMVDDVPLPPTHKLTMSEV---YDDPKTGKP----NFDALRQHFLLEGRIEEAVALRIITEG 108
            |.:|...|..:.........||   |..|:...|    :..||.:.|.|:.::.....|.::.|.
Human    89 TEDRFAQDSEMKKCSDYESIEVPDSYTGPRLSFPLLPDHATALVEAFRLKQQLHARYVLNLLYET 153

  Fly   109 AALLREEKNMIDVEA----PITVCGDIHGQFFDLVKLFEVGGPPATTR-YLFLGDYVDRGYFSIE 168
            ...|.:..|:..|..    .||||||:|||..||:.:|...|.|:..| |:|.||:||||..|:|
Human   154 KKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVE 218

  Fly   169 CVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKY---SESIYDACMEAFDCLPLAAL 230
            .::.|::..:.||....|.|||||...:...:.|.:|.:.||   .:.|.....:.|..||||.|
Human   219 ILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATL 283

  Fly   231 LNQQFLCIHGGLS--PEIFTLDDI---KTLNRFR-------------------EPPAYGPM---- 267
            ::::.|.:|||:|  .::..||.|   |.::..|                   :..|.||:
Human   284 IDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFL 348

  Fly   268 ----------------------------------------------------C------------ 268
                                                                |
Human   349 PESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSSVELELERCRQQAGLLVTGEK 413

  Fly   269 -----------------------------DLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSA 304
                                         |:|||||:...|.:.       |::||...:|....
Human   414 EEPSRSASEADSEAGELRKPTQEEWRQVVDILWSDPMAQEGCKA-------NTIRGGGCYFGPDV 471

  Fly   305 CCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM 369
            ..:.|||.|:..::|:||.:..||......:|      :|||||.||.:|.:|:.|.:|....:
Human   472 TQQLLQKYNMQFLIRSHECKPEGYEFCHNRKV------LTIFSASNYYEVGSNRGAYVKLGPAL- 529

  Fly   370 NIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDE---------LVAGPDDEL 425
                   :||             .:.:...|||..|.....|...:|         |.|...|.|
Human   530 -------TPH-------------IVQYQANKVTHTLTMRQRISRVEESALRALREKLFAHSSDLL 574

  Fly   426 EE--------------------------------ELRKKIVLVPANASN--------NNNNNNTP 450
            .|                                .||.:  ||.::|.|        .|......
Human   575 SEFKKHDADKVGLITLSDWAAAVESVLHLGLPWRMLRPQ--LVNSSADNMLEYKSWLKNLAKEQL 637

  Fly   451 SKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGAL 500
            |:....|:|.:.:.||:    ..:..:|.|:..:....:.|.....|..|
Human   638 SRENIQSSLLETLYRNR----SNLETIFRIIDSDHSGFISLDEFRQTWKL 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	103/436 (24%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	96/399 (24%)
PPEF2	NP_006230.2	MPP_RdgC	122..537	CDD:277364	103/448 (23%)
		Catalytic	128..540		102/445 (23%)
		PP2Ac	141..540	CDD:197547	98/432 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..382		3/63 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..435		0/25 (0%)
		EFh	657..722	CDD:238008	5/27 (19%)
		EF-hand_7	657..721	CDD:290234	5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..753
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900