Protein Alignment CanA1 and Ppp3cc

DIOPT Version :9

• Sequence 1: NP_001247378.2
• Gene: CanA1 / 43670
• FlyBaseID: FBgn0010015
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001291920.1
• Gene: Ppp3cc / 19057
• MGIID: 107162
• Length: 522
• Species: Mus musculus
• Alignment Length: 505
• Identity: 355/505 - (70%)
• Similarity: 414/505 - (81%)
• Gaps: 35/505 - (6%)

  Fly    51 TRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREE 115
            |.||::..||.|||.:||:.||:::   |||..|.|:.|.:.|||:||.|||:||.:|||:|::|
Mouse    10 TTERVIKAVPFPPTRRLTLKEVFEN---GKPKMDLLKNHLVKEGRVEEEVALKIINDGAAILKQE 71

  Fly   116 KNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITY 180
            |.||:||||||||||:|||||||:|||||||.|:.||||||||||||||||||||||||||||.:
Mouse    72 KTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINH 136

  Fly   181 PTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPE 245
            |.||.|||||||||||||||||||||.|||||.:|||||..||||||||||||||||:|||:|||
Mouse   137 PKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPE 201

  Fly   246 IFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310
            |..|:||:.|:||.||||:||:|||||||||||:|:|||.|.::||:||||||||||.|.|||||
Mouse   202 ITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQ 266

  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 375
            .|:||||:|||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse   267 NNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 331

  Fly   376 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANA 440
            |||||||||||||||||||||||||||||||||||||||:|:     :..:||
Mouse   332 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEM-----NVTDEE------------ 379

  Fly   441 SNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGAL 505
                 ::...|.|...:..|||:|:|||||||||:|||::||||||:||.||||||||.||:|.|
Mouse   380 -----DHYISSCPKGATTGRKEVIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVL 439

  Fly   506 SGGRDSL----------KEALQGLTASSHIHSFAEAKGLDAVNERMPPRR 545
            |||:.::          :||::|.|.:..|.||.||:|||.:|||||||:
Mouse   440 SGGKQTIETAKQEAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	247/303 (82%)
		PP2Ac	98..369	CDD:197547	223/270 (83%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	247/303 (82%)
		Catalytic. /evidence=ECO:0000305	52..343		242/290 (83%)
		PP2Ac	54..325	CDD:197547	223/270 (83%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		21/21 (100%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	394..408		11/13 (85%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	409..416		3/6 (50%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	467..489		14/21 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..522		7/9 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832385
Domainoid	1	1.000	89	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.720