DRSC/TRiP Functional Genomics Resources

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Protein Alignment CanA1 and Ppp3ca

DIOPT Version :10

Sequence 1:NP_524600.3 Gene:CanA1 / 43670 FlyBaseID:FBgn0010015 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_032939.1 Gene:Ppp3ca / 19055 MGIID:107164 Length:521 Species:Mus musculus


Alignment Length:538 Identity:373/538 - (69%)
Similarity:436/538 - (81%) Gaps:42/538 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 TRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREE 115
            |.:|:|..||.||:|:||..||:|:  .|||..|.|:.|.:.|||:||:||||||||||::||:|
Mouse    13 TTDRVVKAVPFPPSHRLTAKEVFDN--DGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQE 75

  Fly   116 KNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITY 180
            ||::|::||:|||||||||||||:|||||||.||.||||||||||||||||||||||||:|||.|
Mouse    76 KNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILY 140

  Fly   181 PTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPE 245
            |.||.|||||||||||||||||||||.|||||.:|||||:||||||||||:||||||:|||||||
Mouse   141 PKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPE 205

  Fly   246 IFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310
            |.|||||:.|:||:||||||||||:||||||||||||||.|.|:||:|||||||:||.|.|:|||
Mouse   206 INTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQ 270

  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 375
            .||||||:|||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
Mouse   271 HNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 335

  Fly   376 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANA 440
            ||||||||||||||||||||||||||||||||:|||||||||  |.:::                
Mouse   336 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--GSEED---------------- 382

  Fly   441 SNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGAL 505
                      ....:.:|.|||:|||||||||||:||||:|||||||||.||||||||.||.|.|
Mouse   383 ----------GFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVL 437

  Fly   506 SGGRDSLK----------EALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVT 560
            |||:.:|:          ||::|.:....|.||.||||||.:||||||||..:  .|.:::.::.
Mouse   438 SGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM--PSDANLNSIN 500

  Fly   561 RSSSSSSNNNNNNSNTSS 578
            ::.:|.:|..::|.:.||
Mouse   501 KALASETNGTDSNGSNSS 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CanA1NP_524600.3 MPP_PP2B 81..385 CDD:277361 254/303 (84%)
Ppp3caNP_032939.1 MPP_PP2B 41..345 CDD:277361 254/303 (84%)
Catalytic. /evidence=ECO:0000305 56..340 242/283 (86%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209 327..336 8/8 (100%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871 341..369 27/27 (100%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871 392..406 12/13 (92%)
Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871 407..414 4/6 (67%)
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871 465..487 15/21 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521 17/46 (37%)

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