DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and pph-5

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001367002.1	Gene:	pph-5 / 180263	WormBaseID:	WBGene00012665	Length:	496	Species:	Caenorhabditis elegans

Alignment Length:	397	Identity:	121/397 - (30%)
Similarity:	191/397 - (48%)	Gaps:	51/397 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RSSVTRKSSLSKSSSSDKSAKSSSNS-------SKSPTAASGNKQKMQYTKTRERMVDDVPLPPT 64
            :.::|...::.|...:||.|::..:.       .|...|.|.:..|....:|.:          .
Worm   113 KKALTDYQAVVKVCPNDKDARAKFDECSKIVRRQKFEAAISTDHDKKTVAETLD----------I 167

  Fly    65 HKLTMSEVYDDPKTGKPNFDALRQHFLL--------EGRIEEAVALRIITEGAALLREEKNMIDV 121
            :.:.:.:.||.|:..    |.:.:.|:|        :.::.:..|.:::.|....::....|:::
Worm   168 NAMAIEDSYDGPRLE----DKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEI 228

  Fly   122 EAP----ITVCGDIHGQFFDLVKLFEVGGPPATTR-YLFLGDYVDRGYFSIECVLYLWSLKITYP 181
            ..|    .|:|||:||||:||..:||:.|.|:.|. |||.||:||||.||:|.:..:...|:.||
Worm   229 TVPTGKKFTICGDVHGQFYDLCNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYP 293

  Fly   182 TTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEI 246
            ....:.|||||...:.:.:.|:.|...||::.:.|...|.|..|||..|:|::....||||..|.
Worm   294 NHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKED 358

  Fly   247 -FTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310
             .||:||:..:|.|:||..|.|||||||||....|...        |.||....|......::.:
Worm   359 GVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQPINGRSP--------SKRGVGCQFGPDVTSKWCE 415

  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQ 373
            .|.:..:||:||.:..||.|:...|      ..|:||||||.|..|||.|.:..  :|.......
Worm   416 TNGIEYVVRSHEVKPEGYEMHHNGQ------CFTVFSAPNYCDQMNNKGAFITITGDNLTPRFTP 474

  Fly   374 FNCSPHP 380
            |:..|||
Worm   475 FDAVPHP 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	108/316 (34%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	101/278 (36%)
pph-5	NP_001367002.1	PLN03088	29..>139	CDD:215568	5/25 (20%)
		TPR repeat	33..57	CDD:276809
		TPR repeat	62..91	CDD:276809
		TPR repeat	96..124	CDD:276809	1/10 (10%)
		MPP_PP5_C	176..490	CDD:277362	111/324 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000