DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and tax-6

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001367052.1	Gene:	tax-6 / 177943	WormBaseID:	WBGene00006527	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	368/573 - (64%)
Similarity:	433/573 - (75%)	Gaps:	43/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSKSSSSDKSAKSSSNSSKSPTAASGNKQK----MQYTKTRERMVDDVPLPPTHKLTMSEVYDDP 76
            ::.:|:...||.....::.:.||::.|:::    .|:|   ||.|..|..|.:.:||:.:|| |.
Worm     1 MASTSAGQNSAAKPDTTNTTTTASNNNRERERDLKQFT---ERFVKTVQFPVSERLTVDQVY-DR 61

  Fly    77 KTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKL 141
            :||||..:.||.||:.||||||..|:|:|.|.::|.|.||.|:::|||:||||||||||:||:||
Worm    62 RTGKPRHEVLRDHFIKEGRIEEEAAIRVIQECSSLFRNEKTMLEIEAPVTVCGDIHGQFYDLMKL 126

  Fly   142 FEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQEC 206
            |||||.||||:||||||||||||||||||||||:|||.|||||.|||||||||||||||||||||
Worm   127 FEVGGSPATTKYLFLGDYVDRGYFSIECVLYLWALKICYPTTLFLLRGNHECRHLTEYFTFKQEC 191

  Fly   207 IIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLL 271
            .|||||.:||.|||:||.||||||:||||||:||||||||.||:||:.::||:||||:|||||||
Worm   192 KIKYSERVYDVCMESFDALPLAALMNQQFLCVHGGLSPEIHTLEDIRRIDRFKEPPAFGPMCDLL 256

  Fly   272 WSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQV 336
            |||||||||||:.:|.||||||||||||:||:|||:|||.||||||:|||||||||||||||:|.
Worm   257 WSDPLEDFGNERNSEQFSHNSVRGCSYFYSYAACCDFLQHNNLLSIIRAHEAQDAGYRMYRKSQA 321

  Fly   337 TGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKV 401
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Worm   322 TGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKV 386

  Fly   402 TEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASNNNNNNNTPSKPASMSALRKEIIRN 466
            |||||:||||||||||:|..||..|                        .....:.:.|||:||:
Worm   387 TEMLVHILNICSDDELMAECDDTFE------------------------GADGGVGSARKEVIRH 427

  Fly   467 KIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEAL---QGLTA-----SS 523
            ||||||||:|.||:||.|||||||||||...|.||.||||.||..|..|.   |.:.|     |.
Worm   428 KIRAIGKMARAFSVLRHESESVLQLKGLNAGGKLPQGALSEGRTGLNAAYRIEQSVAAESGCDSG 492

  Fly   524 H-IHSFAEAKGLDAVNERMPP--RRPLLMSASSSSITTVTRSSSSSSNNNNNN 573
            | |.||.||:.||.:||||||  ..|...|.|.|.|.:...:.....|..:|:
Worm   493 HLIQSFEEARRLDKINERMPPTMATPPAQSPSQSPIPSRQTTPQPPQNGPSNS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	246/303 (81%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	220/270 (81%)
tax-6	NP_001367052.1	MPP_PP2B	66..370	CDD:277361	246/303 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156843
Domainoid	1	1.000	296	1.000	Domainoid score	I796
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	787	1.000	Inparanoid score	I260
Isobase	1	0.950	-	0.740582	Normalized mean entropy	S271
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		otm14372
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.860