DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA1 and Ppp3cc

DIOPT Version :9

Sequence 1:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_008769035.1	Gene:	Ppp3cc / 171378	RGDID:	621616	Length:	515	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	358/516 - (69%)
Similarity:	420/516 - (81%)	Gaps:	38/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SGNKQKMQYTKTRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRI 104
            ||.:.:.   .|.||::..||.|||.:||:.||:::   |||..|.|:.|.:.|||:||.|||:|
  Rat     2 SGRRPQF---STTERVIKAVPFPPTRRLTLKEVFEN---GKPKMDVLKNHLVKEGRVEEDVALKI 60

  Fly   105 ITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIEC 169
            |.:|||:|::||.|::||||||||||:|||||||:|||||||.|:.|||||||||||||||||||
  Rat    61 INDGAAILKQEKTMLEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIEC 125

  Fly   170 VLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQ 234
            |||||||||.:|.||.|||||||||||||||||||||.|||||.:|:|||..|||||||||||||
  Rat   126 VLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKYSELVYEACMHTFDCLPLAALLNQQ 190

  Fly   235 FLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYF 299
            |||:|||:||||..||||:.|:||.||||:||:|||||||||||:|:|||.|.::||:|||||||
  Rat   191 FLCVHGGMSPEITCLDDIRKLDRFAEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYF 255

  Fly   300 FSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKY 364
            |||.|.|||||.|:||||:|||||||||||||||||.||||||||||||||||||||||||||||
  Rat   256 FSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKY 320

  Fly   365 ENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEEL 429
            ||||||||||||||||||||||||||||||||||||||||||||||||||:|:     ..:|||
  Rat   321 ENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEM-----SLVEEE- 379

  Fly   430 RKKIVLVPANASNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGL 494
                            ::...|.|...:::|||:|||||||||||:|||::||||||:||.||||
  Rat   380 ----------------DHYISSCPKGATSVRKEVIRNKIRAIGKMARVFTVLREESENVLILKGL 428

  Fly   495 TPTGALPVGALSGGRDSL----------KEALQGLTASSHIHSFAEAKGLDAVNERMPPRR 545
            ||||.||:|.||||:.::          :||::|.|.:..|.||.||:|||.:|||||||:
  Rat   429 TPTGTLPLGVLSGGKQTIETAKLQAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	246/303 (81%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	222/270 (82%)
Ppp3cc	XP_008769035.1	MPP_PP2B	37..341	CDD:277361	246/303 (81%)
Ppp3cc	XP_008769035.1	PP2Ac	54..325	CDD:197547	222/270 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336040
Domainoid	1	1.000	92	1.000	Domainoid score	I7405
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.720