Protein Alignment 5-HT7 and TAAR2

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001028252.1
• Gene: TAAR2 / 9287
• HGNCID: 4514
• Length: 351
• Species: Homo sapiens
• Alignment Length: 389
• Identity: 96/389 - (24%)
• Similarity: 153/389 - (39%)
• Gaps: 123/389 - (31%)

  Fly   150 FAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALL 214
            |.||        |||:          |:.||:.:.|::...::|..|.|:|::|:|::|..:...
Human    49 FMAG--------SIFI----------TIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFT 95

  Fly   215 VMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRT---- 275
            :||.:::..|...|.||...|.|:.|||::....||.:||::::||:.||..||.|..|.|
Human    96 IMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVI 160

  Fly   276 PRRMMLCVGIVWLAAACISLPPLLILGNEHEDE-----EGQPICTVCQN----FAYQIYAT---L 328
            .|.::||    |      |:|.....|....:.     ||..|...|.:    ...:::.|   :
Human   161 KRLLLLC----W------SVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFM 215

  Fly   329 GSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQ 393
            ..|:.|.|:|:.:|.:||..:|:    ...|..:|::..|.
Human   216 AGFFTPGSMMVGIYGKIFAVSRK----HAHAINNLRENQNN------------------------ 252

  Fly   394 RHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGI 458
                                                               |:.|:|||:.||||
Human   253 ---------------------------------------------------QVKKDKKAAKTLGI 266

  Fly   459 IMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            ::..|.:||.|.|...|:.||.....|..|.....|.||.||..||:||......||:..:.||
Human   267 VIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYIL 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	90/370 (24%)
		TM helix 1	164..190	CDD:320452	5/25 (20%)
		TM helix 2	197..223	CDD:320452	7/25 (28%)
		TM helix 3	235..265	CDD:320452	12/29 (41%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	8/35 (23%)
		TM helix 6	447..477	CDD:320452	14/29 (48%)
		TM helix 7	486..511	CDD:320452	10/24 (42%)
TAAR2	NP_001028252.1	7tmA_TAAR2_3_4	44..326	CDD:320437	94/383 (25%)
		TM helix 1	45..71	CDD:320437	10/39 (26%)
		TM helix 2	78..104	CDD:320437	7/25 (28%)
		TM helix 3	116..146	CDD:320437	12/29 (41%)
		TM helix 4	158..181	CDD:320437	7/32 (22%)
		TM helix 5	206..235	CDD:320437	8/28 (29%)
		TM helix 6	255..285	CDD:320437	14/29 (48%)
		TM helix 7	294..319	CDD:320437	10/24 (42%)