Protein Alignment 5-HT7 and TAAR8

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_444508.1
• Gene: TAAR8 / 83551
• HGNCID: 14964
• Length: 342
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 109/427 - (25%)
• Similarity: 174/427 - (40%)
• Gaps: 115/427 - (26%)

  Fly   109 LASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVI 173
            :.|..|.|:..:.|:.:..|.:           :||     ::.|..|:......|.|::
Human     1 MTSNFSQPVVQLCYEDVNGSCI-----------ETP-----YSPGSRVILYTAFSFGSLL----- 44

  Fly   174 LGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIW 238
              .|.||:||..:|...::|..|.|:|:.|||.:|..|.:.||..:::..|...|.||...|.:.
Human    45 --AVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLH 107

  Fly   239 VSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG- 302
            ...||..|.:|:|:||.|.:|||:.:|.||.|..|.|.....:|:.:.|:.       ||...|
Human   108 SCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWIL-------PLTYSGA 165

  Fly   303 ----NEHEDEEGQPICTV-----CQNFAYQIYATLG--SFYIPLSVMLFVYYQIFRAARRIVLEE 356
                ..::|...:.:..:     ||....|.:..:.  .|:||..||:.:|.:||..|:
Human   166 VFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAK------ 224

  Fly   357 KRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGH 421
                   |||:.               .|..|       |.|.::|.:|
Human   225 -------QQAIK---------------IETTS-------SKVESSSESY---------------- 244

  Fly   422 GSGGGVSGSTGLLGSPHHKKLRFQLAK-EKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVP 485
                                 :.::|| |:||:.|||:.:.||.:.|||:.:..||..|.....|
Human   245 ---------------------KIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTP 288

  Fly   486 ASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            |.:..:..|..|.||.:||:|||.....|||..:.||
Human   289 AYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	98/367 (27%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	9/25 (36%)
		TM helix 3	235..265	CDD:320452	12/29 (41%)
		TM helix 4	277..299	CDD:320452	3/21 (14%)
		TM helix 5	319..348	CDD:320452	9/30 (30%)
		TM helix 6	447..477	CDD:320452	14/30 (47%)
		TM helix 7	486..511	CDD:320452	10/24 (42%)
TAAR8	NP_444508.1	7tmA_TAAR6_8_9	32..321	CDD:320439	99/374 (26%)
		TM helix 1	33..59	CDD:320439	8/32 (25%)
		TM helix 2	66..92	CDD:320439	9/25 (36%)
		TM helix 3	104..134	CDD:320439	12/29 (41%)
		TM helix 4	146..169	CDD:320439	5/29 (17%)
		TM helix 5	193..222	CDD:320439	9/28 (32%)
		TM helix 6	250..280	CDD:320439	13/29 (45%)
		TM helix 7	289..314	CDD:320439	10/24 (42%)