Protein Alignment 5-HT7 and adra1aa

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001311383.1
• Gene: adra1aa / 798498
• ZFINID: ZDB-GENE-030131-2831
• Length: 485
• Species: Danio rerio
• Alignment Length: 439
• Identity: 138/439 - (31%)
• Similarity: 212/439 - (48%)
• Gaps: 85/439 - (19%)

  Fly   137 LVPLSD--TPLLLEEFA-----AGEFVLPPLT---SIFVSIVLLIVILGTVVGNVLVCIAVCMVR 191
            :||..|  ||   |.|.     ..:.::|.|.   ::.:.:||.|.|:..|:||:||.::|...|
Zfish     8 MVPFKDNMTP---ESFPENCSNCSQVLVPELNVMKAVALGVVLAIFIVFGVLGNILVILSVACHR 69

  Fly   192 KLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAI 256
            .||...:|.:|:||::||.::..|:|.:.::|:|.:|.||...||:|.:.|||||||||::||.|
Zfish    70 NLRTVTHYFIVNLAVADLLLSSTVLPFSTVFEMLGRWIFGRPFCDVWAAMDVLCCTASIMSLCVI 134

  Fly   257 SVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFA 321
            |||||:.::.||:|....|.||.:|.:..:|:.:..||:.||  .|.:....:.:.||.:.:...
Zfish   135 SVDRYIGVSYPLQYPSIVTERRALLALIALWVLSITISIGPL--FGWKEPAPDDESICKITEEPG 197

  Fly   322 YQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTEL 386
            |.|::.|||||:||.|:|.:|.:::..|||    |.|            |..|..:.....|.|.
Zfish   198 YAIFSALGSFYLPLVVILSMYCRVYVVARR----ETR------------GLISGQKTEKSDHAET 246

  Fly   387 ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKK 451
            .:                             |..|.....||....|....|......:.::|||
Zfish   247 VT-----------------------------LRIHRGNMTVSEDEALRNRTHFALRLLKFSREKK 282

  Fly   452 ASTTLGIIMSAFTVCWLPFFILALI-------RPFETMHVPASLSSLFLWLGYANSLLNPIIYAT 509
            |:.||||::..|.:||||||::..|       ||.:|:.      .:..||||.||.:|||||..
Zfish   283 AAKTLGIVVGCFVLCWLPFFLVLPIGSIFPTYRPSDTVF------KITFWLGYFNSCINPIIYPC 341

  Fly   510 LNRDFRKPFQEILYFRCSSLNTMMRENYYQDQYGEPPSQRVMLGDERHG 558
            .:::|:|.|..:|..||....:......||..            ..|||
Zfish   342 SSQEFKKAFLSVLGARCLRKRSTPSHTLYQSH------------SPRHG 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	120/361 (33%)
		TM helix 1	164..190	CDD:320452	10/25 (40%)
		TM helix 2	197..223	CDD:320452	8/25 (32%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	7/21 (33%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	16/36 (44%)
		TM helix 7	486..511	CDD:320452	11/24 (46%)
adra1aa	NP_001311383.1	7tm_GPCRs	41..350	CDD:475119	120/361 (33%)
		TM helix 1	43..67	CDD:410628	10/23 (43%)
		TM helix 2	76..98	CDD:410628	8/21 (38%)
		TM helix 3	114..136	CDD:410628	14/21 (67%)
		TM helix 4	159..175	CDD:410628	4/15 (27%)
		TM helix 5	196..219	CDD:410628	11/22 (50%)
		TM helix 6	284..306	CDD:410628	11/21 (52%)
		TM helix 7	318..343	CDD:410628	12/30 (40%)