Protein Alignment 5-HT7 and htr1ab

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001139238.1
• Gene: htr1ab / 797538
• ZFINID: ZDB-GENE-090409-2
• Length: 403
• Species: Danio rerio
• Alignment Length: 416
• Identity: 163/416 - (39%)
• Similarity: 232/416 - (55%)
• Gaps: 52/416 - (12%)

  Fly   141 SDTPLLLE-----EFAAGEFVLP---PLT-SIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRP 196
            :||..|.:     :.......||   ||: .|..|:::..:||.::.||..|..|:.:.|.|:..
Zfish     5 NDTSFLFQNDSDLDHQTDNVTLPVKVPLSYQISTSLLIGALILCSIFGNACVVAAIALERSLQNV 69

  Fly   197 CNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRY 261
            .|||:.|||::||.|::||:|||.||:||:||..|.:.|||::|.|:||||:|||:||||::|||
Zfish    70 ANYLIGSLAVTDLMVSVLVLPMAALYQVLDKWTLGQVTCDIFISLDILCCTSSILHLCAIALDRY 134

  Fly   262 LAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQP-ICTVCQNFAYQIY 325
            .|||.|::|..|||.:|..|.:.:.|.....||:||:||:       :.|| .|.:..:..|.||
Zfish   135 WAITDPIDYMKKRTLKRAALLITVTWFVGFSISIPPMLIM-------KSQPKTCMISHDPWYTIY 192

  Fly   326 ATLGSFYIPLSVMLFVYYQIFRAARRIVL------EEKRAQ-----THLQQALNGTGS---PSAP 376
            :|..:|||||.:||.:|.:||:|||..:.      |:||.:     ..|.:..||..|   .||.
Zfish   193 STFCAFYIPLILMLVLYGRIFKAARFRIRKTVRKPEKKRVKCLTVSPALFKRANGELSKNWKSAV 257

  Fly   377 QAPPLGHTELASSGNGQ-RHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHK 440
            :..|      |:..||. :|:..|. ||........|.....|.      ....|..|..:.|.|
Zfish   258 EPKP------AACVNGAIKHAEDGE-SLEIIEVHSNSKNNLPLP------NTPNSVPLFENKHEK 309

  Fly   441 ----KLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF-ETMHVPASLSSLFLWLGYANS 500
                |.:..||:|:|...||||||..|.:|||||||.||:.|| .|..:|..|..:..||||:||
Zfish   310 NTEAKRKLALARERKTVKTLGIIMGTFILCWLPFFIKALVMPFCPTCVMPLWLQDVINWLGYSNS 374

  Fly   501 LLNPIIYATLNRDFRKPFQEILYFRC 526
            ||||||||..|:||:..|::|:  :|
Zfish   375 LLNPIIYAYFNKDFQSAFKKII--KC 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	153/375 (41%)
		TM helix 1	164..190	CDD:320452	7/25 (28%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	7/21 (33%)
		TM helix 5	319..348	CDD:320452	14/28 (50%)
		TM helix 6	447..477	CDD:320452	19/29 (66%)
		TM helix 7	486..511	CDD:320452	15/24 (63%)
htr1ab	NP_001139238.1	7tm_GPCRs	36..392	CDD:475119	153/375 (41%)
		TM helix 1	38..62	CDD:320453	7/23 (30%)
		TM helix 2	71..93	CDD:320453	13/21 (62%)
		TM helix 3	109..131	CDD:320453	15/21 (71%)
		TM helix 4	154..170	CDD:320453	4/15 (27%)
		TM helix 5	187..210	CDD:320453	11/22 (50%)
		TM helix 6	326..348	CDD:320453	14/21 (67%)
		TM helix 7	360..385	CDD:320453	15/24 (63%)