Protein Alignment 5-HT7 and drd1a

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_021336831.1
• Gene: drd1a / 792634
• ZFINID: ZDB-GENE-130522-1
• Length: 363
• Species: Danio rerio
• Alignment Length: 402
• Identity: 141/402 - (35%)
• Similarity: 192/402 - (47%)
• Gaps: 101/402 - (25%)

  Fly   160 LTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLR-RPCNYLLVSLALSDLCVALLVMPMALLYE 223
            ||..|:|    ::||.|::||.|||.||...|.|| :..|:.::|||:|||.||:||||...:.|
Zfish    26 LTGCFLS----LLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAVSDLLVAILVMPWKAVTE 86

  Fly   224 VLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWL 288
            |...|.|| ..|||||:||::|.||||||||.||||||.||:.|..|..|.|||...:.:.:.|.
Zfish    87 VAGFWPFG-AFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPRVAFVMISVAWT 150

  Fly   289 AAACISLPPLLILGNEHEDEEGQPI----------------CTVCQNFAYQIYATLGSFYIPLSV 337
            .:..||..|:.:     :..:.||.                |....|..|.|.::|.|||||:::
Zfish   151 LSVLISFIPVQL-----KWHKAQPTSFPEANASHRALLTDNCDSSLNRTYAISSSLISFYIPVAI 210

  Fly   338 MLFVYYQIFRAA----RRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSV 398
            |:..|.||:|.|    |||...|:                 |.::..:.|..:.||.|....||.
Zfish   211 MIVTYTQIYRIAQKQIRRISALER-----------------AAESAKIRHDSMGSSSNVDSESSF 258

  Fly   399 GNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAF 463
                                                      ||.|:  :|.|...||.:||..|
Zfish   259 ------------------------------------------KLSFK--RETKVLKTLSVIMGVF 279

  Fly   464 TVCWLPFFILALIRPF---ETMHVPA---SLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            ..||||||||..:.||   .::.:|.   :...:|:|.|:|||.||||||| .|.|||:.|..:|
Zfish   280 VCCWLPFFILNCMVPFCKRTSVGLPCISPTTFDVFVWFGWANSSLNPIIYA-FNADFRRAFAILL 343

  Fly   523 YFR--CSSLNTM 532
            ..:  |...|:|
Zfish   344 GCQRLCPGSNSM 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	134/381 (35%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	23/29 (79%)
		TM helix 4	277..299	CDD:320452	5/21 (24%)
		TM helix 5	319..348	CDD:320452	13/28 (46%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	13/27 (48%)
drd1a	XP_021336831.1	7tm_GPCRs	24..339	CDD:475119	136/384 (35%)
		TM helix 1	27..51	CDD:410628	13/27 (48%)
		TM helix 2	61..83	CDD:410628	13/21 (62%)
		TM helix 3	98..120	CDD:410628	16/21 (76%)
		TM helix 4	143..159	CDD:410628	3/15 (20%)
		TM helix 5	193..216	CDD:410628	9/22 (41%)
		TM helix 6	269..291	CDD:410628	13/21 (62%)
		TM helix 7	308..333	CDD:410628	13/25 (52%)