Protein Alignment 5-HT7 and hrh2a

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001038803.2
• Gene: hrh2a / 735303
• ZFINID: ZDB-GENE-070531-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 388
• Identity: 127/388 - (32%)
• Similarity: 185/388 - (47%)
• Gaps: 95/388 - (24%)

  Fly   161 TSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL 225
            :.|.:::.|.::||.||.||:|||:||...|:||...|..:||||::|..:..||:|.:.||:|.
Zfish     3 SQIALAVTLSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTLYQVT 67

  Fly   226 EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAA 290
            ..|..|...|:|::|.||:.||||||||.|||:|||.|:|.||.|.:...|.|:...:..:||.:
Zfish    68 GDWPLGAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAILATIWLVS 132

  Fly   291 ACISLPPL--------LILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFR 347
            ..:|..|:        |.:.|..|.:..:. |....|..|.|.....:||:||..|.:.|:::||
Zfish   133 VGVSFVPIHLGWNTRDLSVQNIREGDHARD-CRFELNPTYAIVDAFSTFYLPLLAMCWSYHRVFR 196

  Fly   348 AAR---RIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCG 409
            .||   :.::..:|..|                                  ||.|.|.||
Zfish   197 IARMRAKRIISTRRGST----------------------------------SSQGVTILT----- 222

  Fly   410 GLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLP---FF 471
                                                 .:|.||:.||.:::.||.|||.|   ||
Zfish   223 -------------------------------------LREHKATVTLAVVLGAFVVCWFPYFTFF 250

  Fly   472 ILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILY--FRCSSLNTM 532
            .:..||..|  :.|.:..|:.||||||||.|||::|||||||||..:.::|.  .||.:..|:
Zfish   251 TIMGIRNEE--NPPQTAQSVVLWLGYANSALNPVLYATLNRDFRSAYAKLLCGGRRCKTETTI 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	123/368 (33%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	5/29 (17%)
		TM helix 5	319..348	CDD:320452	10/28 (36%)
		TM helix 6	447..477	CDD:320452	13/32 (41%)
		TM helix 7	486..511	CDD:320452	15/24 (63%)
hrh2a	NP_001038803.2	7tmA_Histamine_H2R	5..295	CDD:320179	123/368 (33%)
		TM helix 1	6..32	CDD:320179	12/25 (48%)
		TM helix 2	39..66	CDD:320179	11/26 (42%)
		TM helix 3	77..107	CDD:320179	20/29 (69%)
		TM helix 4	119..139	CDD:320179	4/19 (21%)
		TM helix 5	168..198	CDD:320179	11/29 (38%)
		TM helix 6	223..253	CDD:320179	13/29 (45%)
		TM helix 7	263..288	CDD:320179	15/24 (63%)