DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Htr7

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_038945768.1	Gene:	Htr7 / 65032	RGDID:	71034	Length:	508	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	151/373 - (40%)
Similarity:	212/373 - (56%)	Gaps:	52/373 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-E 226
            :.:..:|.::.|.|:.||.||.|:||.|:|||:|.|||:|||||:||.||:.|||...:.::: .
  Rat    85 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 149

  Fly   227 KWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAA 291
            ||.||...|:::::.||:||||||:.||.||:||||.||:||.|.|::..:.|...:..|||.:|
  Rat   150 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSA 214

  Fly   292 CISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEE 356
            .|:||||........|::   :|.:.|:|.|.||:|..:||||:|||||:||||::|||:...:.
  Rat   215 SITLPPLFGWAQNVNDDK---VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH 276

  Fly   357 KRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGH 421
            |              .|..|:..|    |...|.||     |.........|..||.
  Rat   277 K--------------FPGFPRVQP----ESVISLNG-----VVKLQKEVEECANLSR-------- 310

  Fly   422 GSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF----ETM 482
                       ||  .|.:|......:|:||:||||||:.||||||||||:|:..|||    ...
  Rat   311 -----------LL--KHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 362

  Fly   483 HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN 530
            .:|..:....|||||||||:||.|||..|||.|..::.:|..:..::|
  Rat   363 CIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNIN 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	83/169 (49%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	139/332 (42%)
Htr7	XP_038945768.1	7tmA_5-HT7	100..398	CDD:320452	146/344 (42%)
		TM helix 2	120..142	CDD:320452	15/21 (71%)
		TM helix 3	159..181	CDD:320452	11/21 (52%)
		TM helix 4	204..220	CDD:320452	6/15 (40%)
		TM helix 5	240..263	CDD:320452	14/22 (64%)
		TM helix 6	329..351	CDD:320452	17/21 (81%)
		TM helix 7	366..391	CDD:320452	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20244
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327781at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106732
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850