Protein Alignment 5-HT7 and htr6

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_009295353.2
• Gene: htr6 / 568269
• ZFINID: ZDB-GENE-030131-7839
• Length: 540
• Species: Danio rerio
• Alignment Length: 427
• Identity: 139/427 - (32%)
• Similarity: 186/427 - (43%)
• Gaps: 83/427 - (19%)

  Fly   165 VSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWN 229
            ::::|.::||.|..||:|:...|...|.||...|..||||.||||.|||:|||.|:|..:...|.
Zfish   112 LAVMLSLIILVTACGNILLIALVFAHRSLRCTSNCFLVSLFLSDLMVALVVMPPAMLNVLCGTWV 176

  Fly   230 FGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACIS 294
            ..|..|.:|:.|||:||:|||||||.||:||||.|..||.|....||.|.:|.||..|..||..|
Zfish   177 LAPGFCPVWLCFDVMCCSASILNLCVISLDRYLLIISPLRYKQHMTPPRALLLVGGAWGLAALTS 241

  Fly   295 LPPLLI----LGNEHEDEEGQP-------------------------ICTVCQNFAYQIYATLGS 330
            ..|:.:    ||...|..|..|                         .|.:.....:.:.||..:
Zfish   242 FLPIKMDWHSLGRMQELTEDDPGNATHLNSFYPSSYFQLSSSGMPSTQCRLRVTLPFALVATFLT 306

  Fly   331 FYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRH 395
            |::|.:.:.|.|.:|..|||| ...:..|.||.....:..|.||.|.:|  ||.  ...|:...|
Zfish   307 FFLPSTAICFTYCRILLAARR-QARQVEALTHPAYPQHSLGEPSRPPSP--GHA--IQDGDDYSH 366

  Fly   396 SSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEK-----KASTT 455
            ..                                ..||..:|.......:||..:     |||.|
Zfish   367 QE--------------------------------PPGLRHAPLSVNSERRLAHRQRKRALKASLT 399

  Fly   456 LGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQE 520
            ||:::..|...||||||..:.:.. ...||.|......||||.||.:|||||....|||::....
Zfish   400 LGVLLGLFFSAWLPFFITNMAQAV-CECVPPSFFDAITWLGYCNSTMNPIIYPMFMRDFKRALAR 463

  Fly   521 ILYFRCSS----------LNTMMRENYYQDQYGEPPS 547
            :|.. |||          |:..:|.:.......||||
Zfish   464 LLPC-CSSSQAPRRPSLPLSLSLRNSGEPQLPSEPPS 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	129/386 (33%)
		TM helix 1	164..190	CDD:320452	8/24 (33%)
		TM helix 2	197..223	CDD:320452	17/25 (68%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	9/21 (43%)
		TM helix 5	319..348	CDD:320452	7/28 (25%)
		TM helix 6	447..477	CDD:320452	14/34 (41%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
htr6	XP_009295353.2	None