Protein Alignment 5-HT7 and drd1b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001129448.1
• Gene: drd1b / 568126
• ZFINID: ZDB-GENE-070524-2
• Length: 446
• Species: Danio rerio
• Alignment Length: 384
• Identity: 132/384 - (34%)
• Similarity: 186/384 - (48%)
• Gaps: 86/384 - (22%)

  Fly   160 LTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLR-RPCNYLLVSLALSDLCVALLVMPMALLYE 223
            ||..|:|    ::||.|::||.|||.||...|.|| :..|:.::|||:|||.||:||||.....|
Zfish    23 LTGCFLS----LLILTTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAISDLLVAILVMPWKAATE 83

  Fly   224 VLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWL 288
            ::..|.|| ..||:||:||::|.||||||||.||||||.||:.|..|..|.||:...:.:.:.|.
Zfish    84 IVGFWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWT 147

  Fly   289 AAACISLPPLLILGNEHEDE------------EGQP-ICTVCQNFAYQIYATLGSFYIPLSVMLF 340
            .:..||..|:.:  |.|:.:            |..| .|....|..|.|.::|.|||||:::||.
Zfish   148 LSILISFIPVQL--NWHKAQTTSYTELNGTYGELPPDNCDSSLNRTYAISSSLISFYIPVAIMLV 210

  Fly   341 VYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTY 405
            .|.:|:|.|::                         |...:...|.|:.....||||:||.:...
Zfish   211 TYTRIYRIAQK-------------------------QIRRISALERAAESAKNRHSSMGNNASME 250

  Fly   406 STCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPF 470
            |                                ....:....:|.|...||.:||..|..|||||
Zfish   251 S--------------------------------ESSFKMSFKRETKVLKTLSVIMGVFVCCWLPF 283

  Fly   471 FILALIRPF-------ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            |:|..:.||       :.:.:.::...:|:|.|:|||.||||||| .|.||||.|..:|
Zfish   284 FVLNCMVPFCNPNESTDFLCISSTTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSILL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	128/375 (34%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	22/29 (76%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	13/28 (46%)
		TM helix 6	447..477	CDD:320452	14/29 (48%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
drd1b	NP_001129448.1	7tm_GPCRs	21..337	CDD:475119	130/378 (34%)
		TM helix 1	24..48	CDD:320443	13/27 (48%)
		TM helix 2	58..80	CDD:320443	13/21 (62%)
		TM helix 3	95..117	CDD:320443	15/21 (71%)
		TM helix 4	140..156	CDD:320443	3/15 (20%)
		TM helix 5	190..213	CDD:320443	10/22 (45%)
		TM helix 6	266..288	CDD:320443	12/21 (57%)
		TM helix 7	306..331	CDD:320443	13/25 (52%)