Protein Alignment 5-HT7 and htr7b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_693673.3
• Gene: htr7b / 565304
• ZFINID: ZDB-GENE-091118-105
• Length: 404
• Species: Danio rerio
• Alignment Length: 423
• Identity: 160/423 - (37%)
• Similarity: 225/423 - (53%)
• Gaps: 69/423 - (16%)

  Fly   116 PIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLT-SIFVSIVLLIVILGTVVG 179
            |.|:.:.:..::.:.|:..|                    :.|.|| ::.|.::|..:...||:|
Zfish    29 PTALTTAEPRSNGSCGEQRT--------------------LDPDLTKTVIVGLMLSSITAVTVMG 73

  Fly   180 NVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWVSFDV 243
            |.||.||||:|:|||:|.||||||||::||.||:.|||.|::.::. ..|.||.:.|:|::..||
Zfish    74 NTLVVIAVCVVKKLRQPSNYLLVSLAIADLSVAVAVMPFAIVTDLTGGVWLFGEVFCNIFIGMDV 138

  Fly   244 LCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHE-D 307
            :||||||:.||.|||||||.||:||.|..::..:.|...:..|||.:|.|:|||  ..|..|. :
Zfish   139 MCCTASIMTLCVISVDRYLGITRPLTYPARQNGQLMAKMIVGVWLVSASITLPP--FCGWAHNVN 201

  Fly   308 EEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGS 372
            ..|  :|.:.|:..|.:|:|..:||||:.||||:||:||:||||      ....|     |.|..
Zfish   202 TAG--VCLISQDVGYTLYSTAVAFYIPMVVMLFMYYKIFKAARR------SGAKH-----NFTSL 253

  Fly   373 PSAPQAPPLGHTELASSGNGQRHS-SVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGS 436
            |....|.|  ...||:......|. ..|.||..:||   ||.                   ||..
Zfish   254 PPIQLACP--EPALATVDGFCMHGMKNGATSEEFST---LSC-------------------LLNR 294

  Fly   437 PHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF----ETMHVPASLSSLFLWLGY 497
            .......|:  :|:||:||||:||..|:.||||||:....|||    .....|..|..:.|||||
Zfish   295 ERRSASIFR--REQKAATTLGVIMGVFSFCWLPFFLFTTARPFICGLLCNCAPVWLERVLLWLGY 357

  Fly   498 ANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN 530
            .|||:||.|||..|||.|..::::|..|..::|
Zfish   358 TNSLMNPFIYAFFNRDLRSTYKDLLRCRYRNIN 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	150/361 (42%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	16/25 (64%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	9/21 (43%)
		TM helix 5	319..348	CDD:320452	15/28 (54%)
		TM helix 6	447..477	CDD:320452	16/29 (55%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
htr7b	XP_693673.3	None