DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and htr7b

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021329876.1	Gene:	htr7b / 565304	ZFINID:	ZDB-GENE-091118-105	Length:	404	Species:	Danio rerio

Alignment Length:	423	Identity:	160/423 - (37%)
Similarity:	225/423 - (53%)	Gaps:	69/423 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLT-SIFVSIVLLIVILGTVVG 179
            |.|:.:.:..::.:.|:..|                    :.|.|| ::.|.::|..:...||:|
Zfish    29 PTALTTAEPRSNGSCGEQRT--------------------LDPDLTKTVIVGLMLSSITAVTVMG 73

  Fly   180 NVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWVSFDV 243
            |.||.||||:|:|||:|.||||||||::||.||:.|||.|::.::. ..|.||.:.|:|::..||
Zfish    74 NTLVVIAVCVVKKLRQPSNYLLVSLAIADLSVAVAVMPFAIVTDLTGGVWLFGEVFCNIFIGMDV 138

  Fly   244 LCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHE-D 307
            :||||||:.||.|||||||.||:||.|..::..:.|...:..|||.:|.|:|||  ..|..|. :
Zfish   139 MCCTASIMTLCVISVDRYLGITRPLTYPARQNGQLMAKMIVGVWLVSASITLPP--FCGWAHNVN 201

  Fly   308 EEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGS 372
            ..|  :|.:.|:..|.:|:|..:||||:.||||:||:||:||||      ....|     |.|..
Zfish   202 TAG--VCLISQDVGYTLYSTAVAFYIPMVVMLFMYYKIFKAARR------SGAKH-----NFTSL 253

  Fly   373 PSAPQAPPLGHTELASSGNGQRHS-SVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGS 436
            |....|.|  ...||:......|. ..|.||..:||   ||.                   ||..
Zfish   254 PPIQLACP--EPALATVDGFCMHGMKNGATSEEFST---LSC-------------------LLNR 294

  Fly   437 PHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF----ETMHVPASLSSLFLWLGY 497
            .......|:  :|:||:||||:||..|:.||||||:....|||    .....|..|..:.|||||
Zfish   295 ERRSASIFR--REQKAATTLGVIMGVFSFCWLPFFLFTTARPFICGLLCNCAPVWLERVLLWLGY 357

  Fly   498 ANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN 530
            .|||:||.|||..|||.|..::::|..|..::|
Zfish   358 TNSLMNPFIYAFFNRDLRSTYKDLLRCRYRNIN 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	83/170 (49%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	139/334 (42%)
htr7b	XP_021329876.1	7tmA_5-HT7	57..378	CDD:320452	150/361 (42%)
		TM helix 1	58..84	CDD:320452	12/25 (48%)
		TM helix 2	91..117	CDD:320452	16/25 (64%)
		TM helix 3	130..160	CDD:320452	19/29 (66%)
		TM helix 4	172..194	CDD:320452	9/23 (39%)
		TM helix 5	211..240	CDD:320452	15/28 (54%)
		TM helix 6	303..333	CDD:320452	16/31 (52%)
		TM helix 7	346..371	CDD:320452	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327781at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106732
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.940