DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT7 and htr7a

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021323081.1	Gene:	htr7a / 562111	ZFINID:	ZDB-GENE-130530-666	Length:	479	Species:	Danio rerio

Alignment Length:	452	Identity:	166/452 - (36%)
Similarity:	234/452 - (51%)	Gaps:	75/452 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLE--EFAAG----EFVLP 158
            ||..:.:.|..||:..|                        |.:|:|||  |.|.|    |.:|.
Zfish    58 SGEVAVAAGSGSMDMKP------------------------SSSPILLEMMEVANGTRCAEQILS 98

  Fly   159 --PLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALL 221
              .:..:.:..||.::.|.|:.||:||.|:||.|:|||:|.|||:|||||:||.|||.|||...:
Zfish    99 YGEVEKVLIGGVLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPFVSI 163

  Fly   222 YEVL-EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGI 285
            .::: .:|.||...|:::::.||:||||||:.||.||:||||.||:||.|.|::....|...|..
Zfish   164 TDLIGGRWIFGKFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAKMVLS 228

  Fly   286 VWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAAR 350
            |||.:|.|:||||........|:.   :|.:.|:|.|.||:|..:||||::|||.:||:|||||:
Zfish   229 VWLLSASITLPPLFGWAQNVNDDR---VCLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFRAAK 290

  Fly   351 RIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYS--------T 407
                  ..|..|     ..||.|...| ..:...|:...|........|...:|.:        .
Zfish   291 ------LSAAKH-----TITGFPRVEQ-EEVEEDEVEEDGGNGAEEPTGVDCVTVAIKLQREVEE 343

  Fly   408 CGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFI 472
            |..|..   .|.|.|.......|..:            ..:|:||:.||||::.|||:||||||:
Zfish   344 CARLPR---ILRGVGRRCSDRRSISI------------FKREQKAAATLGIVVGAFTICWLPFFL 393

  Fly   473 LALIRPF----ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN 530
            |:..|||    |...:|..:....|||||||||:||.|||..|||.|..::.:|..|..::|
Zfish   394 LSTARPFICGTECSCIPLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYRSLLSCRYRNIN 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	82/169 (49%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	136/340 (40%)
htr7a	XP_021323081.1	7tmA_5-HT7	105..443	CDD:320452	147/367 (40%)
		TM helix 1	106..132	CDD:320452	11/25 (44%)
		TM helix 2	139..165	CDD:320452	16/25 (64%)
		TM helix 3	178..208	CDD:320452	17/29 (59%)
		TM helix 4	220..242	CDD:320452	10/21 (48%)
		TM helix 5	259..288	CDD:320452	16/28 (57%)
		TM helix 6	368..398	CDD:320452	17/29 (59%)
		TM helix 7	411..436	CDD:320452	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20244
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327781at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106732
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850