Protein Alignment 5-HT7 and htr1d

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001139158.1
• Gene: htr1d / 556429
• ZFINID: ZDB-GENE-090409-3
• Length: 386
• Species: Danio rerio
• Alignment Length: 410
• Identity: 154/410 - (37%)
• Similarity: 220/410 - (53%)
• Gaps: 58/410 - (14%)

  Fly   133 SNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPC 197
            |.|||....|..||             ...|.:|.:|.||.|.|.:.|..|...:.:.|||..|.
Zfish    18 SPTTLESWDDATLL-------------SLQISISAMLAIVTLATALSNAFVIATIFLTRKLHTPA 69

  Fly   198 NYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYL 262
            |:|:.|||.:||.|::||||::::|.|.:.|..|.::||||:|.|:..||||||:||.|::|||.
Zfish    70 NFLIGSLAATDLLVSILVMPISIVYTVSKTWTLGQIVCDIWLSSDITFCTASILHLCVIALDRYW 134

  Fly   263 AITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLL-ILGNEHEDEEGQPICTVC----QNFAY 322
            |||..|||..:||.||..|.:.|||:.:..||||||. .....||:      .|.|    ...:|
Zfish   135 AITDALEYSKRRTMRRAALMIVIVWVISVSISLPPLFWRQAKAHEE------LTECMVNTDQISY 193

  Fly   323 QIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELA 387
            .:|:|.|:||:|..:::.:|.:|:.|||..:.:        ..|.:|....:|         :|.
Zfish   194 TLYSTFGAFYVPTVLLMILYGRIYVAARSRIFK--------TPATSGKRFTAA---------QLI 241

  Fly   388 SSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKL--------RF 444
            .:..|....|:.:||   :..|.|::|||  .|.|.|||..|.:.|..:....||        |.
Zfish   242 QNSAGSSLCSLNSTS---NQEGHLNAGGG--GGSGGGGGGGGGSPLFTNSVKVKLADSVLERKRL 301

  Fly   445 QLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYANSLLNPIIY 507
            ..|:||||:.|||||:.||.|||||||:..|:...  :..:.|. |..:|.||||.|||:||:||
Zfish   302 CAAREKKATKTLGIILGAFIVCWLPFFVFTLVMGVCKDCWYHPV-LFDVFTWLGYLNSLINPVIY 365

  Fly   508 ATLNRDFRKPFQEILYF-RC 526
            ...|.||::.|.:::.| ||
Zfish   366 TAFNDDFKQAFHKLIKFKRC 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	143/369 (39%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	11/21 (52%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	20/29 (69%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
htr1d	NP_001139158.1	7tmA_5-HT1B_1D	31..376	CDD:320455	144/386 (37%)
		TM helix 1	36..62	CDD:320455	8/25 (32%)
		TM helix 2	69..95	CDD:320455	12/25 (48%)
		TM helix 3	107..137	CDD:320455	19/29 (66%)
		TM helix 4	149..172	CDD:320455	12/22 (55%)
		TM helix 5	190..219	CDD:320455	9/28 (32%)
		TM helix 6	304..334	CDD:320455	20/29 (69%)
		TM helix 7	344..369	CDD:320455	14/25 (56%)