Protein Alignment 5-HT7 and drd4b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 426
• Identity: 129/426 - (30%)
• Similarity: 209/426 - (49%)
• Gaps: 86/426 - (20%)

  Fly   127 SSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVR 191
            |:|:   ::||.|           |...:.:|.|  :| .|:|:|||   :.||||||::|...:
Zfish     2 SANI---SSTLQP-----------ALFTYNVPAL--VF-GILLIIVI---ICGNVLVCLSVYKEK 46

  Fly   192 KLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLE--KWNFGPLLCDIWVSFDVLCCTASILNLC 254
            .|:...||.:||||::||.:|:||:|: .:|...:  .|:....:||..::.||:.|||||.|||
Zfish    47 ALKTTTNYFIVSLAVADLMLAVLVLPL-FVYAEFQGGVWSLNVSVCDGLMTMDVMLCTASIFNLC 110

  Fly   255 AISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQN 319
            ||||||::|::.||.|..|....|.::.:...||.|..::.|.:..:.|..:.:..:  |.:..|
Zfish   111 AISVDRFIAVSIPLNYNRKHVDYRQIILLSATWLLALAVASPVIFGINNVPQRDPSE--CKLEDN 173

  Fly   320 FAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGS----PSAPQAPP 380
             .|.:|:::.||:||..:||.:|:.:|...|:  .||.| :..|:.::....|    ..|...||
Zfish   174 -NYVVYSSVCSFFIPCPIMLMLYFGMFHGLRK--WEETR-KAKLRNSIQACRSLQHAAVAAALPP 234

  Fly   381 LG----------HTELASSGNGQ---------------RHSSVGNTSLTYSTCGGLSSGGGALAG 420
            ||          ..:||.|...:               ::|::  .::.||..
Zfish   235 LGALPASLPRVIERDLAQSSLEELDDFTQPVCPFPPEYKNSTI--QTVAYSDI------------ 285

  Fly   421 HGSGGGVSGSTGLLGSPHHKKLRFQL-AKEKKASTTLGIIMSAFTVCWLPFFILALIRPF-ETMH 483
                        ..|....:|.|.:: .:|:||...|.:::..|..||.|||::...|.. |:.|
Zfish   286 ------------QYGQKTQRKKRAKINGRERKAMRVLPVVVGVFLFCWTPFFVVHTTRALCESCH 338

  Fly   484 VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQ 519
            :.:.|.|...||||.||.||||||...|.:|||.|:
Zfish   339 ISSDLMSTVTWLGYVNSALNPIIYTVFNTEFRKFFR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	120/387 (31%)
		TM helix 1	164..190	CDD:320452	13/25 (52%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	5/21 (24%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	10/29 (34%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	121/391 (31%)
		TM helix 1	20..45	CDD:320434	14/30 (47%)
		TM helix 2	52..78	CDD:320434	13/26 (50%)
		TM helix 3	91..121	CDD:320434	19/29 (66%)
		TM helix 4	133..156	CDD:320434	5/22 (23%)
		TM helix 5	172..201	CDD:320434	11/29 (38%)
		TM helix 6	301..331	CDD:320434	10/29 (34%)
		TM helix 7	341..366	CDD:320434	14/24 (58%)