Protein Alignment 5-HT7 and drd4a

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001012634.2
• Gene: drd4a / 503564
• ZFINID: ZDB-GENE-070112-996
• Length: 380
• Species: Danio rerio
• Alignment Length: 380
• Identity: 122/380 - (32%)
• Similarity: 198/380 - (52%)
• Gaps: 59/380 - (15%)

  Fly   168 VLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLE-KWNFG 231
            :|||:|:  :.||||||::|...:.|:...||.:||||::||.:|:||:|:.:..|..: .|:..
Zfish    28 ILLIIII--ICGNVLVCLSVYTEKALKTTTNYFIVSLAVADLLLAVLVLPLFVYAEFQDGVWSLN 90

  Fly   232 PLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLP 296
            ..:||..::.||:.|||||.||||||:||::|::.||.|..|...:|.::.:...|:.|..::.|
Zfish    91 MTVCDGLMTMDVMLCTASIFNLCAISIDRFIAVSIPLNYNRKHVDQRQIVLLSATWILALAVASP 155

  Fly   297 PLLILGN----EHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEK 357
            .:..:.|    :|.:      |.:..| .|.||:::.||::|..:||.:|..:||..|.  .||.
Zfish   156 VMFGINNVPNRDHSE------CKLEDN-NYVIYSSVCSFFVPCPIMLLLYCGMFRGLRN--WEEA 211

  Fly   358 R---------AQTHLQQALNG----TGSPSAPQAPPLGHTELASSGNGQRH-----SSVGNTSLT 404
            |         |...||:|...    :|.|  |..||:...::......|.|     |....:.|.
Zfish   212 RKAKLRSNMEACRKLQEAAASLQPLSGLP--PPLPPVIEKDITLEELDQDHYPDPDSPDPVSMLA 274

  Fly   405 YSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQL-AKEKKASTTLGIIMSAFTVCWL 468
            |                 .|||.:...    :.:.::.|.:: .:|:||...|.:::.||..||.
Zfish   275 Y-----------------PGGGYNQDQ----NQNRQRKRAKINGRERKAMRVLPVVVGAFLFCWT 318

  Fly   469 PFFILALIRPF-ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            |||::..:|.. |...:|.|::|:..||||.||.:|||||...|.:|||.|::.|
Zfish   319 PFFVVHTMRALCEDCEIPGSVTSIVTWLGYVNSAINPIIYTVFNTEFRKFFRKFL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	120/374 (32%)
		TM helix 1	164..190	CDD:320452	11/21 (52%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	18/29 (62%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	11/29 (38%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
drd4a	NP_001012634.2	7tmA_D4_dopamine_R	36..369	CDD:320434	116/364 (32%)
		TM helix 2	55..81	CDD:320434	12/25 (48%)
		TM helix 3	94..124	CDD:320434	18/29 (62%)
		TM helix 4	136..159	CDD:320434	4/22 (18%)
		TM helix 5	175..204	CDD:320434	11/29 (38%)
		TM helix 6	297..327	CDD:320434	11/29 (38%)
		TM helix 7	337..362	CDD:320434	13/24 (54%)