Protein Alignment 5-HT7 and adra1bb

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001007359.1
• Gene: adra1bb / 492486
• ZFINID: ZDB-GENE-041114-51
• Length: 481
• Species: Danio rerio
• Alignment Length: 399
• Identity: 134/399 - (33%)
• Similarity: 200/399 - (50%)
• Gaps: 88/399 - (22%)

  Fly   144 PLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSD 208
            ||||..            ::.:.:||...|...:.||:||.::|...|.||.|.||.:|:||::|
Zfish    41 PLLLSR------------AVPLGLVLGFFITFAIAGNILVILSVVCNRHLRSPTNYFIVNLAIAD 93

  Fly   209 LCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVK 273
            |.:...|:|::...||:..|.||.:.||:|.:.|||||||||::||.||:|||:.::.||:|...
Zfish    94 LLLGTTVLPVSATLEVVGHWVFGRIFCDVWAAVDVLCCTASIMSLCVISIDRYIGVSHPLQYPNI 158

  Fly   274 RTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVM 338
            .|.||.:|.:..||:.:..||:.||  ||.:........:|.:.:...|.::::||||||||.|:
Zfish   159 VTGRRALLAMLGVWVLSLVISIGPL--LGWKEPPSPDDTVCAINEEPFYALFSSLGSFYIPLIVI 221

  Fly   339 LFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSG--------NGQRH 395
            |.:|.:::..|       ||...:|:..:.               ||..:||        ..|.|
Zfish   222 LVMYCRVYVVA-------KRTTKNLEAGVK---------------TESMNSGEITLRIHRGSQVH 264

  Fly   396 SSVGNT-------SLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKAS 453
            ...|.:       |||.                                  |.|:|  ::||||:
Zfish   265 EDAGKSRAHQARNSLTV----------------------------------KLLKF--SREKKAA 293

  Fly   454 TTLGIIMSAFTVCWLPFFILALIRPFET-MHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKP 517
            .|||:::..||:||||||:...|..|.| :..|.::||:..||||.||.||||||...:|:|:..
Zfish   294 KTLGVVVGMFTLCWLPFFLTLPIVSFNTSLRPPETVSSIIFWLGYFNSCLNPIIYPCYSREFKLA 358

  Fly   518 FQEILYFRC 526
            |..||..||
Zfish   359 FIRILKCRC 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	125/370 (34%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	9/25 (36%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
adra1bb	NP_001007359.1	7tm_GPCRs	48..359	CDD:475119	125/370 (34%)
		TM helix 1	50..74	CDD:410628	8/23 (35%)
		TM helix 2	83..105	CDD:410628	9/21 (43%)
		TM helix 3	121..143	CDD:410628	14/21 (67%)
		TM helix 4	166..182	CDD:410628	5/15 (33%)
		TM helix 5	203..226	CDD:410628	11/22 (50%)
		TM helix 6	293..315	CDD:410628	11/21 (52%)
		TM helix 7	327..352	CDD:410628	14/24 (58%)