DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT7 and TyrRII

DIOPT Version :10

Sequence 1:NP_524599.1 Gene:5-HT7 / 43669 FlyBaseID:FBgn0004573 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster


Alignment Length:605 Identity:166/605 - (27%)
Similarity:249/605 - (41%) Gaps:197/605 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PIAIVSYQGITSSNL----GDSNTT-----LVPLSDTP---LLLEEFAAGEFVLPPLTSIFVSI- 167
            |.|::.|..:.|:.|    |:||::     |:..|..|   ::.....||:..:|.:.|..||: 
  Fly     7 PDAMLPYSKLLSTALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMA 71

  Fly   168 --------VLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEV 224
                    |.|::||.|||||.||.:||...|:||...|..:::||::|..|...|||.:::..:
  Fly    72 WPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYI 136

  Fly   225 LEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRM-MLCVGIVWL 288
            ...|.||.:|||||:|.|:|.|:.|||:|||||:|||||:|:||.|..||..:|: :|.:.:||:
  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201

  Fly   289 AAACISLPPLLILG----NEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQI---F 346
            .|..|:.||  .||    ..|:.|...  |...||..|.:::.:|||:|||:|||:||.:|   .
  Fly   202 TALSITCPP--YLGWYEVGRHQAEFVD--CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVL 262

  Fly   347 RAARRIVLEEKRAQTHLQQALNGTG----------SP--------------SAPQAPPLGHTELA 387
            .:.|:.::.:..::......::|..          :|              |....||...|..|
  Fly   263 TSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAA 327

  Fly   388 SSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGST-------------------GL 433
            :.|    |.|    |:..|.|...||..|. ||.|:|.||...|                   .|
  Fly   328 AKG----HQS----SVKCSKCSKCSSATGT-AGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSL 383

  Fly   434 L---------GSP---------------------------------------------------- 437
            :         |.|                                                    
  Fly   384 IHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAK 448

  Fly   438 ------------------------------HHKKLRFQLA---KEKKASTTLGIIMSAFTVCWLP 469
                                          ||.::..:::   ::.|.:.||.|:|.....||||
  Fly   449 QKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLP 513

  Fly   470 FFILALIRPFETMHVPASLSSL---FLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNT 531
            ||:..|:.||  :..||.|..|   |.|:|:.|..:||.|||..|.|||..|..:   .|..:..
  Fly   514 FFVYYLLIPF--LPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRL---TCRPICK 573

  Fly   532 MMRENYYQDQYGEPPSQRVM 551
            ..|          ||:...|
  Fly   574 QKR----------PPNHLAM 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT7NP_524599.1 7tmA_5-HT7 163..518 CDD:320452 145/511 (28%)
TM helix 1 164..190 CDD:320452 15/34 (44%)
TM helix 2 197..223 CDD:320452 8/25 (32%)
TM helix 3 235..265 CDD:320452 21/29 (72%)
TM helix 4 277..299 CDD:320452 8/22 (36%)
TM helix 5 319..348 CDD:320452 14/31 (45%)
TM helix 6 447..477 CDD:320452 12/32 (38%)
TM helix 7 486..511 CDD:320452 12/27 (44%)
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 84/195 (43%)
TM helix 1 78..101 CDD:410628 13/22 (59%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 14/21 (67%)
TM helix 4 194..210 CDD:410628 5/15 (33%)
TM helix 5 233..256 CDD:410628 11/22 (50%)
7tm_GPCRs <491..563 CDD:475119 31/73 (42%)
TM helix 6 497..519 CDD:320098 10/21 (48%)
TM helix 7 531..556 CDD:320098 10/24 (42%)

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