Protein Alignment 5-HT7 and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 546
• Identity: 172/546 - (31%)
• Similarity: 249/546 - (45%)
• Gaps: 118/546 - (21%)

  Fly    55 VPAPLVEGETESATSQDFNSSSAFLGAIASASSTGSGSGSGSGSGSGSGSGSYGLASMNSSPIAI 119
            |..|:..|::.:..::   .::|.|...|...:|.:.:.:||.|.|.|.:|...|....::|..
  Fly    49 VSNPISYGQSLTTLAR---VTAAALTTAAMLHTTNALAATGSSSASNSSTGGIALPLGTATPAT- 109

  Fly   120 VSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAG-------------EFVLPPLTSIFVSIVLLI 171
                       .:.|.| .|...:.|...|..||             |..|..:..:|.:.|:|:
  Fly   110 -----------HELNAT-QPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLL 162

  Fly   172 VILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCD 236
            :|:..:.||:||.|:|..|||||...||.:||||::|:.||::.|......:|..:|||.|.|||
  Fly   163 IIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCD 227

  Fly   237 IWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIV----WLAAACISLPP 297
            :|.|.||...|||||:||.||||||.||.|||:|.:..|.|    .|||:    |::.|.:|..|
  Fly   228 LWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKR----VVGIMLLNTWISPALLSFLP 288

  Fly   298 LLI---LGNEHED--EEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEK 357
            :.|   ...:|:.  .:....|:...|..|.:.::..||:||.::|:|.|..|||.|.|   :||
  Fly   289 IFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANR---QEK 350

  Fly   358 RAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHG 422
            :..                                .||   ||..|.:..  .:...|.||:|
  Fly   351 QLM--------------------------------MRH---GNAMLMHRP--SMQPSGEALSG-- 376

  Fly   423 SGGGVSGSTGLL--------GSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFI-LALIRP 478
                 |||:..|        .:|...|...::.:|.||:.||||||..|.:||||||: ..|...
  Fly   377 -----SGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMT 436

  Fly   479 FETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILY-----------------FRC 526
            .|...||..:.|:..|:||.||.|||:|||..|||||:.|:..|.                 .|.
  Fly   437 CEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRR 501

  Fly   527 SSLNTMMR-ENYYQDQY--GEPPSQR 549
            |||....| ::.|.:.|  ...||.|
  Fly   502 SSLRYDQRAKSVYSESYLNSTTPSHR 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	136/372 (37%)
		TM helix 1	164..190	CDD:320452	10/25 (40%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	8/25 (32%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	17/30 (57%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	136/371 (37%)
		TM helix 1	155..181	CDD:320194	10/25 (40%)
		TM helix 2	188..214	CDD:320194	10/25 (40%)
		TM helix 3	226..256	CDD:320194	20/29 (69%)
		TM helix 4	268..291	CDD:320194	8/26 (31%)
		TM helix 5	315..344	CDD:320194	11/28 (39%)
		TM helix 6	404..434	CDD:320194	16/29 (55%)
		TM helix 7	444..469	CDD:320194	12/24 (50%)