Protein Alignment 5-HT7 and 5-HT2B

DIOPT Version :9

• Sequence 1: NP_001263131.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 824
• Identity: 157/824 - (19%)
• Similarity: 226/824 - (27%)
• Gaps: 465/824 - (56%)

  Fly   166 SIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNF 230
            :::.|:::|||..||:|||:|:...|:|:...||.|:|||::||.||:||||:.:|..|...:..
  Fly    77 ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPL 141

  Fly   231 GPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISL 295
            |...|..|:..|||.|||||::||.|||||||::..|:.:|..:|.||:.|.:..|||.:..:||
  Fly   142 GSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL 206

  Fly   296 PPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFR------------- 347
            |..|:....|........|.: .:..|::..::..|||||.|||..|....|
  Fly   207 PLSLMYSKNHASVLVNGTCQI-PDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQ 270

  Fly   348 ---AA---------------------RRI----------VLEEKRA------------------- 359
               ||                     ||:          ||....|
  Fly   271 QTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPD 335

  Fly   360 ----------QTHLQQ----------------ALNGTGS----------------PSAP------ 376
                      .|.|.|                :.:.|||                ||:|
  Fly   336 SSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAAT 400

  Fly   377 -------------------QAPPLG---------------------HTELASSGNG--------- 392
                               ||.|.|                     ...||||..|
  Fly   401 HQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLS 465

  Fly   393 ---------------------------------------------QRHSSV-------------- 398
                                                         :||:|:
  Fly   466 QLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQE 530

  Fly   399 ----------------------------------------------------------------- 398
                                                                             
  Fly   531 SLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGD 595

  Fly   399 ------------------------------------------GN-TSLTYSTCGGLSSG------ 414
                                                      || .|||.|...|::.|
  Fly   596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAP 660

  Fly   415 ---GGALAGH--------------GSG-------------------------------------- 424
               |..|:.|              |||
  Fly   661 ATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSF 725

  Fly   425 GGVSGSTGLLGSP--------------------HHKKLRFQ------------------------ 445
            |||  .|.||.:|                    .|:.:.:|
  Fly   726 GGV--RTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQT 788

  Fly   446 ----------------------LAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASL 488
                                  :..|:||:..||::...|.:.|.|||:|.|: |.........:
  Fly   789 VRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLL-PTVCAECEERI 852

  Fly   489 S----SLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSS 528
            |    .:..|||||:|::|||.|...|:.||:.|:::|..|.||
  Fly   853 SHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSS 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	71/168 (42%)
		7tm_1	179..507	CDD:278431	144/788 (18%)
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	70/172 (41%)
		7tm_4	90..>238	CDD:304433	60/148 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010