DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT7 and mAChR-A

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	163/843 - (19%)
Similarity:	256/843 - (30%)	Gaps:	391/843 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IAYAA-GKATVPAPLVEGETESATSQDFNSSSAFLGAIASASSTGSGSGSGSG------------ 97
            :|.|| |..::..||.:..|.|.|:....::|       :.::|.|.:|...|
  Fly     7 LALAAHGPPSILEPLFKTVTTSTTTTTTTTTS-------TTTTTASPAGYSPGYPGTTLLTALFE 64

  Fly    98 ---SGSGSG-----SGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGE 154
               |.:.||     ||.||               ..|:..:|                .|.....
  Fly    65 NLTSTAASGLYDPYSGMYG---------------NQTNGTIG----------------FETKGPR 98

  Fly   155 FVLPPLTSI-FVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPM 218
            :.|..:..: ||:.:|..|   ||.|||:|.|:..:.::|:...||.|.|||::|..:..:.||:
  Fly    99 YSLASMVVMGFVAAILSTV---TVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPL 160

  Fly   219 ALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCV 283
            ..:..:|..|..||::||.|::.|.|...||:|||..||.|||.::|:||.|..|||..|..:.:
  Fly   161 FAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMI 225

  Fly   284 GIVWLAAACISLPPLLILGNEHEDEEGQP--ICTV--CQNFAYQIYAT-LGSFYIPLSVMLFVYY 343
            |..| ..:.:..||.:......|.:...|  .|.:  .:...|..:.| |.:||.|:::|.|:|:
  Fly   226 GAAW-GISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYW 289

  Fly   344 QIFRAARR--------------------------------------------------------- 351
            :|:|..::
  Fly   290 RIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESS 354

  Fly   352 ----------IVLEE------------------KRA----------------------------- 359
                      :|::.                  |::
  Fly   355 PDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQ 419

  Fly   360 --------------QTHLQQALNGT-------------GSPSAPQAP----------PLGHTELA 387
                          :|.||.:::..             ||.|..:.|          ||....||
  Fly   420 EEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLA 484

  Fly   388 S--------------------SGNGQ---------RHS-------------------SVGN---- 400
            |                    ||||.         .|:                   :.||
  Fly   485 SISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHR 549

  Fly   401 --------------------------------TSLTYSTCGGLSSGGGALA-------------- 419
                                            .|...:..||...|.||.|
  Fly   550 DSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSI 614

  Fly   420 ----------------------------------------------------------------- 419

  Fly   615 KMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAG 679

  Fly   420 GHGSGGGVSGSTGLLGSPH---HKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFET 481
            |..:||||.|:..|:.:.:   .||...:..:|.||:.||..|:.:|.:.|.|:.||.||:|..|
  Fly   680 GGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTT 744

  Fly   482 MH--VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYYQDQY 542
            ..  :|..|...|..|.|.||.:||:.||..|..||:.:..||..:..:.|   ||...:..|
  Fly   745 CSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRN---REGMVRGVY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	59/173 (34%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	121/651 (19%)
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	49/127 (39%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	60/193 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010