DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT7 and 5-HT1A

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	186/752 - (24%)
Similarity:	283/752 - (37%)	Gaps:	284/752 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ISTATLTLFVLFLSSWIAYAAGKATVPAPLVEGETESA-----TSQDFNSSSAFLGAIASASSTG 89
            ::|.|.|......::.:|.||..|:|.|.......::|     |.||..||.|...|:.......
  Fly    96 VNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPALQLIDMDN 160

  Fly    90 SGSGSGSGSGS----------GSGSGSYG-LASMNSSPIAIVSYQG---ITSSNLGDSNTTLVPL 140
            :.:....|.|:          |:.|..:| :.:..|..:.:::..|   :|:|.:.:.:.|.:
  Fly   161 NYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQL-- 223

  Fly   141 SDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLA 205
                               |.....|::|.::||.|::|||.|..|:.:.|.|:...|||:.|||
  Fly   224 -------------------LRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLA 269

  Fly   206 LSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEY 270
            ::||.||.||||:..:||:.:.|..||.|||||.|.||||||||||:|.||:||||.|:|. ::|
  Fly   270 VADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDY 333

  Fly   271 GVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHED---EEGQPICTVCQNFAYQIYATLGSFY 332
            ...||..|:.:.:..||.||..:||.|.  .|.:..|   ...|..|.|.|:.:||::||..:||
  Fly   334 IHSRTSNRVFMMIFCVWTAAVIVSLAPQ--FGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFY 396

  Fly   333 IPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNG---------------------------- 369
            :||.|:|.:|::|::.||:.:  .:|....:..|:|.
  Fly   397 VPLLVILALYWKIYQTARKRI--HRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKS 459

  Fly   370 -TGSPSAPQAPPLG-------------------HTELASSG--------------NGQRHSSVG- 399
             |||......|..|                   .||.:||.              :|.:.::|.
  Fly   460 KTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSH 524

  Fly   400 ----------NTSLTYSTCGGLSSGG-----GALAGHG--------------------------- 422
                      :|:.:.:...|::..|     |....||
  Fly   525 LVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMT 589

  Fly   423 ---------------------------------------SGGGVSGSTG---------------- 432
                                                   ||||...||.
  Fly   590 AAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTP 654

  Fly   433 ------------------------------LLGS---------------------PHH------- 439
                                          |.|:                     ||.
  Fly   655 TSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQ 719

  Fly   440 -----------------KKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF-ETMHVPA 486
                             :|...:..:|:||:.||.||..||.|||||||::||..|. ....:..
  Fly   720 QQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISD 784

  Fly   487 SLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILY 523
            |::||||||||.||.|||:||...:.:||:.|:.||:
  Fly   785 SVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILF 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	81/171 (47%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	146/566 (26%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	85/188 (45%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	23/29 (79%)
		TM helix 4	340..362	CDD:320454	8/23 (35%)
		TM helix 5	383..412	CDD:320454	12/28 (43%)
		7tm_GPCRs	<743..816	CDD:355774	37/72 (51%)
		TM helix 6	747..772	CDD:341315	15/24 (63%)
		TM helix 7	784..809	CDD:341315	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840