Protein Alignment 5-HT7 and 5-HT1B

DIOPT Version :9

• Sequence 1: NP_001263131.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 199/675 - (29%)
• Similarity: 282/675 - (41%)
• Gaps: 233/675 - (34%)

  Fly    47 AYAAGKATVPAPLVEGETESATSQDFNSSSAFLGAIASASSTGSGSGSGSGSGSGSGSGSYGLAS 111
            |.|||...|||.::|.|..:....:    |.|:                               .
  Fly     8 AMAAGDDDVPASILEIELPAILLNE----SLFI-------------------------------E 37

  Fly   112 MNSSPIAIVSYQGITSSNL----------GDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVS 166
            :|.:...:|.    |:|||          |:.|:....|.|..   :|.||.||.| .:..|.::
  Fly    38 LNGNLTQLVD----TTSNLSQIVWNRSINGNGNSNTFDLVDDE---QERAAVEFWL-LVKMIAMA 94

  Fly   167 IVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFG 231
            :||.::||.|::|||.|..|:.:.|.|:...|||:.|||::||.||.||||:..:||:...|..|
  Fly    95 VVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILG 159

  Fly   232 PLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLP 296
            |.|||||.|.||||||||||:|.||:.|||..:|. ::|...|||||:.|.:..||.||..:||.
  Fly   160 PELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLA 223

  Fly   297 PLLILGNEHED-----EEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEE 356
            |.  .|.:..|     ||..  |.|.|:..|||:||..:||:||.|:||:|::|:..||:.:  :
  Fly   224 PQ--FGWKDPDYMKRIEEQH--CMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRI--Q 282

  Fly   357 KRAQTHLQQALNGTGSPSA---------------------PQAPPLG------------------ 382
            :|||......|..|...||                     .:.|..|
  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRIC 347

  Fly   383 -------------------------------------HTELASSGNGQRHSSVGNTSLT------ 404
                                                 .||.::| |....|..| |.||
  Fly   348 FGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTS-NYDNKSHAG-TELTTVSSDA 410

  Fly   405 --YST-------------------------------------CGGLS------------SGGGAL 418
              |.|                                     .||:.            ||.|.:
  Fly   411 DDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTV 475

  Fly   419 AGHGSGGGVSGS-------------TGL------LGSPHHKKLR----FQLAKEKKASTTLGIIM 460
            ||..:||..|||             .||      :.:||.|..:    .:..:|:||:.||.||.
  Fly   476 AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIIT 540

  Fly   461 SAFTVCWLPFFILALIRPF-ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILY- 523
            .||.:||||||::||.... :...:..:::||||||||.||.|||:||...|.:||:.|:.||:
  Fly   541 GAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFG 605

  Fly   524 ------FRCSSLNTMMRENYYQDQY 542
                  .|.:.:...:::|  :|||
  Fly   606 RKAAARARSAKIXFQLKDN--EDQY 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	85/173 (49%)
		7tm_1	179..507	CDD:278431	153/489 (31%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	89/187 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870