Protein Alignment 5-HT7 and HTR7

DIOPT Version :9

• Sequence 1: NP_001263131.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_062873.1
• Gene: HTR7 / 3363
• HGNCID: 5302
• Length: 479
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 168/459 - (36%)
• Similarity: 240/459 - (52%)
• Gaps: 81/459 - (17%)

  Fly   132 DSNTTLVPLSDTPLLLEEFAAG---EFVLPP--------------LTSIFVSIVLLIVILGTVVG 179
            |.....|..|..|.||.|..|.   .:..||              :..:.:..:|.::.|.|:.|
Human    34 DGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAG 98

  Fly   180 NVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWVSFDV 243
            |.||.|:||.|:|||:|.|||:|||||:||.||:.|||...:.::: .||.||...|:::::.||
Human    99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDV 163

  Fly   244 LCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDE 308
            :||||||:.||.||:||||.||:||.|.|::..:.|...:..|||.:|.|:||||........|:
Human   164 MCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDD 228

  Fly   309 EGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSP 373
            :   :|.:.|:|.|.||:|..:||||:|||||:||||::|||:...:.|              .|
Human   229 K---VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHK--------------FP 276

  Fly   374 SAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPH 438
            ..|:..|  .:.:|.:|..:....|       ..|..||.                   ||  .|
Human   277 GFPRVEP--DSVIALNGIVKLQKEV-------EECANLSR-------------------LL--KH 311

  Fly   439 HKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF----ETMHVPASLSSLFLWLGYAN 499
            .:|......:|:||:||||||:.||||||||||:|:..|||    ....:|..:...||||||||
Human   312 ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYAN 376

  Fly   500 SLLNPIIYATLNRDFRKPFQEILYFRCSSLNTM-----MRENYYQDQYGEPP-------SQRVML 552
            ||:||.|||..|||.|..::.:|..:..::|..     |.|.....:..|.|       ::||:|
Human   377 SLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLL 441

  Fly   553 GDER 556
            ..|:
Human   442 RPEK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	83/169 (49%)
		7tm_1	179..507	CDD:278431	138/332 (42%)
HTR7	NP_062873.1	7tm_1	98..384	CDD:278431	138/332 (42%)
		7tm_4	98..>215	CDD:304433	60/116 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20244
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327781at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106732
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	1	1.000	-	-		X1464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.880