Protein Alignment 5-HT7 and HTR5A

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 130/397 - (32%)
• Similarity: 211/397 - (53%)
• Gaps: 63/397 - (15%)

  Fly   134 NTTLVPLSDTPLLLE-EFAAGEFVL---PPLTSIFVSIVLLIVILGTVVG-----NVLVCIAVCM 189
            |.|...|| ||..|| ..:.|:..|   .||.|:|.  ||::.:||.:|.     |:||...:..
Human     6 NLTSFSLS-TPSPLETNHSLGKDDLRPSSPLLSVFG--VLILTLLGFLVAATFAWNLLVLATILR 67

  Fly   190 VRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWVSFDVLCCTASILNL 253
            ||...|..:.|:.|:|:||:.||.||||::|::|:. .:|..|..||.:|::.|||||||||.|:
Human    68 VRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNV 132

  Fly   254 CAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQ 318
            .||::|||.:||:.:||.::.......:.:.:.|..:|.|||.||| .|......||...|.|.:
Human   133 TAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLL-FGWGETYSEGSEECQVSR 196

  Fly   319 NFAYQIYATLGSFYIPLSVMLFVYYQIFRAAR-RIVLEEKRAQTHLQQALNGTGSPSAPQAPPLG 382
            ..:|.:::|:|:||:||.|:||||::|::||: |:...:..:.:.:.:|:....|...||..
Human   197 EPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMV--- 258

  Fly   383 HTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLA 447
                         .:|.:.::|:..                    .|.|            ::..
Human   259 -------------FTVRHATVTFQP--------------------EGDT------------WREQ 278

  Fly   448 KEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNR 512
            ||::|:..:||::..|.:||:|||:..||.|..:..:||...|:||||||:||..||:||...|:
Human   279 KEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNK 343

  Fly   513 DFRKPFQ 519
            ::...|:
Human   344 NYNSAFK 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	116/361 (32%)
		TM helix 1	164..190	CDD:320452	9/30 (30%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	13/28 (46%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	115/356 (32%)
		TM helix 1	42..68	CDD:320451	7/25 (28%)
		TM helix 2	75..101	CDD:320451	12/25 (48%)
		TM helix 3	114..144	CDD:320451	17/29 (59%)
		TM helix 4	156..177	CDD:320451	5/20 (25%)
		TM helix 5	197..226	CDD:320451	13/28 (46%)
		TM helix 6	278..308	CDD:320451	12/29 (41%)
		TM helix 7	317..342	CDD:320451	14/24 (58%)