| Sequence 1: | NP_001263131.1 | Gene: | 5-HT7 / 43669 | FlyBaseID: | FBgn0004573 | Length: | 564 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000857.1 | Gene: | HTR1F / 3355 | HGNCID: | 5292 | Length: | 366 | Species: | Homo sapiens |
| Alignment Length: | 402 | Identity: | 147/402 - (36%) |
|---|---|---|---|
| Similarity: | 212/402 - (52%) | Gaps: | 58/402 - (14%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 141 SDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLA 205
Fly 206 LSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEY 270
Fly 271 GVKRTPRRMMLCVGIVWLAAACISLPPLL--ILGNEHEDEEGQPICTV-CQNFAYQIYATLGSFY 332
Fly 333 IPLSVMLFVYYQIFRAAR---------RIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELAS 388
Fly 389 SGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQL---AKEK 450
Fly 451 KASTTLGIIMSAFTVCWLPFFILAL-IRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDF 514
Fly 515 RKPFQEILYFRC 526 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT7 | NP_001263131.1 | 7tm_4 | 173..>342 | CDD:304433 | 77/171 (45%) |
| 7tm_1 | 179..507 | CDD:278431 | 125/343 (36%) | ||
| HTR1F | NP_000857.1 | 7tmA_5-HT1F | 24..359 | CDD:320456 | 137/371 (37%) |
| TM helix 1 | 26..50 | CDD:320456 | 9/23 (39%) | ||
| TM helix 2 | 59..81 | CDD:320456 | 13/21 (62%) | ||
| TM helix 3 | 97..119 | CDD:320456 | 14/21 (67%) | ||
| Agonist binding. /evidence=ECO:0000250 | 99..108 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 120..122 | 1/1 (100%) | |||
| TM helix 4 | 142..158 | CDD:320456 | 5/15 (33%) | ||
| TM helix 5 | 179..202 | CDD:320456 | 10/22 (45%) | ||
| TM helix 6 | 292..314 | CDD:320456 | 13/21 (62%) | ||
| Agonist binding. /evidence=ECO:0000250 | 306..310 | 3/3 (100%) | |||
| TM helix 7 | 326..351 | CDD:320456 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 343..347 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | otm40316 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.900 | |||||