Protein Alignment 5-HT7 and HTR1A

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000515.2
• Gene: HTR1A / 3350
• HGNCID: 5286
• Length: 422
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 172/474 - (36%)
• Similarity: 243/474 - (51%)
• Gaps: 95/474 - (20%)

  Fly    87 STGSGSGSGSGSGS-GSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEF 150
            |.|.|:.:.|.... .:|..:.|::.:.      ||||.|||..||
Human     5 SPGQGNNTTSPPAPFETGGNTTGISDVT------VSYQVITSLLLG------------------- 44

  Fly   151 AAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLV 215
                      |.||.:          |:||..|..|:.:.|.|:...|||:.|||::||.|::||
Human    45 ----------TLIFCA----------VLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLV 89

  Fly   216 MPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMM 280
            :|||.||:||.||..|.:.||::::.||||||:|||:||||::|||.|||.|::|..||||||..
Human    90 LPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAA 154

  Fly   281 LCVGIVWLAAACISLPPLLILG-NEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQ 344
            ..:.:.||....||:||:  || ...||......||:.::..|.||:|.|:|||||.:||.:|.:
Human   155 ALISLTWLIGFLISIPPM--LGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGR 217

  Fly   345 IFRAAR-RIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSG-NGQRHSSVGNTSLTYST 407
            |||||| ||....|:.:.        ||:.:...|.|....:.:.:| :|.|:..:|    ..|.
Human   218 IFRAARFRIRKTVKKVEK--------TGADTRHGASPAPQPKKSVNGESGSRNWRLG----VESK 270

  Fly   408 CGGLSSGGGALAGHGSGGG--------VSGSTGLLGSPH--------------------HKKLRF 444
            .||.....||:.....|..        |..|...|..|.                    ..|.:.
Human   271 AGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKM 335

  Fly   445 QLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYANSLLNPIIY 507
            .||:|:|...||||||..|.:|||||||:||:.||  .:.|:|..|.::..||||:||||||:||
Human   336 ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIY 400

  Fly   508 ATLNRDFRKPFQEILYFRC 526
            |..|:||:..|::|:  :|
Human   401 AYFNKDFQNAFKKII--KC 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	153/387 (40%)
		TM helix 1	164..190	CDD:320452	6/25 (24%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	15/28 (54%)
		TM helix 6	447..477	CDD:320452	19/29 (66%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
HTR1A	NP_000515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/17 (24%)
		7tmA_5-HT1A_vertebrates	37..411	CDD:320453	159/426 (37%)
		TM helix 1	38..64	CDD:320453	13/64 (20%)
		TM helix 2	71..97	CDD:320453	15/25 (60%)
		TM helix 3	109..139	CDD:320453	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	8/23 (35%)
		TM helix 5	192..221	CDD:320453	15/28 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..262		6/34 (18%)
		TM helix 6	338..368	CDD:320453	19/29 (66%)
		TM helix 7	379..404	CDD:320453	14/24 (58%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)