Protein Alignment 5-HT7 and HRH2

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 130/397 - (32%)
• Similarity: 193/397 - (48%)
• Gaps: 91/397 - (22%)

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            |.:::||.::||.||.|||:||:||.:.|:||...|..:||||::||.:.|||:|.:.:|::..|
Human    19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCK 83

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |:||.:.|:|:.|.||:.||||||||..||:|||.|:..||.|.|..||.|:.:.:.::|:.:..
Human    84 WSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISIT 148

  Fly   293 ISLPPL-LILGNEHEDEEGQPICTVCQ---NFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIV 353
            :|...: |...:.:|..:|....:.|:   |..|.:...|.:||:||.:|...||:||:.||
Human   149 LSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR--- 210

  Fly   354 LEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGAL 418
                                  .||..:.|                           :||...|
Human   211 ----------------------DQAKRINH---------------------------ISSWKAA- 225

  Fly   419 AGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE-TM 482
                                       ..:|.||:.||..:|.||.:||.|:|...:.|... ..
Human   226 ---------------------------TIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDD 263

  Fly   483 HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN---TMMRENYYQ---DQ 541
            .:...|.::.||||||||.||||:||.||||||..:|::...|.::.|   |.:|.|..|   .|
Human   264 AINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQ 328

  Fly   542 YGEPPSQ 548
            ..||..|
Human   329 SREPRQQ 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	119/359 (33%)
		TM helix 1	164..190	CDD:320452	13/25 (52%)
		TM helix 2	197..223	CDD:320452	11/25 (44%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	3/22 (14%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	15/24 (63%)
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	119/359 (33%)
		TM helix 1	20..46	CDD:320179	13/25 (52%)
		TM helix 2	53..80	CDD:320179	12/26 (46%)
		TM helix 3	91..121	CDD:320179	19/29 (66%)
		TM helix 4	133..153	CDD:320179	3/19 (16%)
		TM helix 5	179..209	CDD:320179	12/29 (41%)
		TM helix 6	227..257	CDD:320179	12/29 (41%)
		TM helix 7	267..292	CDD:320179	15/24 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		7/20 (35%)