DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and HRH2

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001354640.1	Gene:	HRH2 / 3274	HGNCID:	5183	Length:	422	Species:	Homo sapiens

Alignment Length:	397	Identity:	130/397 - (32%)
Similarity:	193/397 - (48%)	Gaps:	91/397 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            |.:::||.::||.||.|||:||:||.:.|:||...|..:||||::||.:.|||:|.:.:|::..|
Human    19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCK 83

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |:||.:.|:|:.|.||:.||||||||..||:|||.|:..||.|.|..||.|:.:.:.::|:.:..
Human    84 WSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISIT 148

  Fly   293 ISLPPL-LILGNEHEDEEGQPICTVCQ---NFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIV 353
            :|...: |...:.:|..:|....:.|:   |..|.:...|.:||:||.:|...||:||:.||
Human   149 LSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVAR--- 210

  Fly   354 LEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGAL 418
                                  .||..:.|                           :||...|
Human   211 ----------------------DQAKRINH---------------------------ISSWKAA- 225

  Fly   419 AGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE-TM 482
                                       ..:|.||:.||..:|.||.:||.|:|...:.|... ..
Human   226 ---------------------------TIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDD 263

  Fly   483 HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN---TMMRENYYQ---DQ 541
            .:...|.::.||||||||.||||:||.||||||..:|::...|.::.|   |.:|.|..|   .|
Human   264 AINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQ 328

  Fly   542 YGEPPSQ 548
            ..||..|
Human   329 SREPRQQ 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	70/172 (41%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	104/332 (31%)
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	119/359 (33%)
		TM helix 1	21..45	CDD:320179	13/23 (57%)
		TM helix 2	54..76	CDD:320179	11/21 (52%)
		TM helix 3	92..114	CDD:320179	13/21 (62%)
		TM helix 4	137..153	CDD:320179	2/15 (13%)
		TM helix 5	180..203	CDD:320179	7/22 (32%)
		TM helix 6	233..255	CDD:320179	9/21 (43%)
		TM helix 7	267..292	CDD:320179	15/24 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910