Protein Alignment 5-HT7 and TAAR6

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_778237.1
• Gene: TAAR6 / 319100
• HGNCID: 20978
• Length: 345
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 103/374 - (27%)
• Similarity: 158/374 - (42%)
• Gaps: 95/374 - (25%)

  Fly   166 SIVLLIVILG-----TVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL 225
            |.|:|.::.|     .|.||:||.|::...::|..|.|:|:.|||.:|..|.:.|||.:::..|.
Human    31 SRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVE 95

  Fly   226 EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAA 290
            ..|.||...|......||..|.:|:.:||.||:|||:|:|.||.|..|.|.....:|:.:.|:.
Human    96 SCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWIL- 159

  Fly   291 ACISLPPLLILG--------NEHEDEEGQPICTV--CQNFAYQ--IYATLGSFYIPLSVMLFVYY 343
                  ||:..|        ::..:|....:..:  ||....|  :.....||:||..:|:.:|.
Human   160 ------PLMYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYG 218

  Fly   344 QIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTC 408
            .||..|||   :.|:        :..|||          .||.:|.....|.:
Human   219 NIFLVARR---QAKK--------IENTGS----------KTESSSESYKARVA------------ 250

  Fly   409 GGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFIL 473
                                                  .:|:||:.|||:.:.||.:.|||:.|.
Human   251 --------------------------------------RRERKAAKTLGVTVVAFMISWLPYSID 277

  Fly   474 ALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            :||..|.....||.:..:..|..|.||.:||:|||.....|||..:.|:
Human   278 SLIDAFMGFITPACIYEICCWCAYYNSAMNPLIYALFYPWFRKAIKVIV 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	102/368 (28%)
		TM helix 1	164..190	CDD:320452	10/28 (36%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	13/29 (45%)
		TM helix 4	277..299	CDD:320452	3/21 (14%)
		TM helix 5	319..348	CDD:320452	9/30 (30%)
		TM helix 6	447..477	CDD:320452	13/29 (45%)
		TM helix 7	486..511	CDD:320452	10/24 (42%)
TAAR6	NP_778237.1	7tmA_TAAR6_8_9	33..322	CDD:320439	101/366 (28%)
		TM helix 1	34..60	CDD:320439	8/25 (32%)
		TM helix 2	67..93	CDD:320439	10/25 (40%)
		TM helix 3	105..135	CDD:320439	13/29 (45%)
		TM helix 4	147..170	CDD:320439	5/29 (17%)
		TM helix 5	194..223	CDD:320439	9/28 (32%)
		TM helix 6	251..281	CDD:320439	13/29 (45%)
		TM helix 7	290..315	CDD:320439	10/24 (42%)