Protein Alignment 5-HT7 and Drd3

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_058836.1
• Gene: Drd3 / 29238
• RGDID: 2521
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 422
• Identity: 144/422 - (34%)
• Similarity: 200/422 - (47%)
• Gaps: 87/422 - (20%)

  Fly   172 VILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLC 235
            :||..:.||.|||.||...|.|:...|||:||||::||.||.||||..:..||. ..|||..:.|
  Rat    39 LILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICC 103

  Fly   236 DIWVSFDVLCCTASILNLCAISVDRYLAITKPLEY--GVKRTP-RRMMLCVGIVWLAAACISLPP 297
            |::|:.||:.||||||||||||:|||.|:..|:.|  |..::. ||:.|.:..||:.|..:|.|
  Rat   104 DVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCP- 167

  Fly   298 LLILGNEHEDEEGQP-ICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQT 361
             |:.|   .:..|.| ||:: .|..:.||:::.|||:|..|.:.||.:|:     |||.:::.:.
  Rat   168 -LLFG---FNTTGDPSICSI-SNPDFVIYSSVVSFYVPFGVTVLVYARIY-----IVLRQRQRKR 222

  Fly   362 HL---------------QQA------------------LNGTGS---------PSAPQAPPLGHT 384
            .|               ||:                  .:.||.         |...|.|.|.|.
  Rat   223 ILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHL 287

  Fly   385 ELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAK- 448
            :..|.  ||.|   |.....||.|...:....:|.|......|..:...|......||..::.|
  Rat   288 QPPSP--GQTH---GGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKL 347

  Fly   449 ----------------------EKKASTTLGIIMSAFTVCWLPFFILALIRPF-ETMHVPASLSS 490
                                  ||||:..:.|::.||.|||||||:..::... :..||...|..
  Rat   348 SNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYR 412

  Fly   491 LFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            ...||||.||.|||:||.|.|.:|||.|.:||
  Rat   413 ATTWLGYVNSALNPVIYTTFNVEFRKAFLKIL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	141/416 (34%)
		TM helix 1	164..190	CDD:320452	9/17 (53%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	21/29 (72%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	15/52 (29%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
Drd3	NP_058836.1	7tmA_D3_dopamine_R	30..440	CDD:320436	141/416 (34%)
		TM helix 1	31..57	CDD:320436	9/17 (53%)
		TM helix 2	64..87	CDD:320436	15/22 (68%)
		TM helix 3	103..133	CDD:320436	21/29 (72%)
		TM helix 4	150..168	CDD:320436	6/19 (32%)
		TM helix 5	185..210	CDD:320436	10/24 (42%)
		TM helix 6	368..398	CDD:320436	14/29 (48%)
		TM helix 7	408..433	CDD:320436	13/24 (54%)