Protein Alignment 5-HT7 and adra2da

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_919345.2
• Gene: adra2da / 266754
• ZFINID: ZDB-GENE-021010-4
• Length: 408
• Species: Danio rerio
• Alignment Length: 399
• Identity: 135/399 - (33%)
• Similarity: 207/399 - (51%)
• Gaps: 60/399 - (15%)

  Fly   159 PLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYE 223
            |.::|.:.:|.||::| |:||||||.:||...|.||.|.|..|||||.:|:.||.||:|.:|..|
Zfish    28 PASAIIILVVSLIILL-TIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLANE 91

  Fly   224 VLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWL 288
            ::..|.||...|..:::.|||.||:||::|||||:|||.::||.:.|.:||||||:...:.:|||
Zfish    92 IMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRIKCMIAVVWL 156

  Fly   289 AAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIV 353
            .:|.||.|||::  .:|:::|    |.:.....|.:.:...||:.|..:|:.||.:|:|.|:
Zfish   157 ISAVISFPPLIM--TKHDEKE----CLINDETWYILSSCAVSFFAPGLIMITVYCKIYRVAK--- 212

  Fly   354 LEEKRAQTHLQQALNG-------------------TGSPSAPQAPPLGHTELASSGNGQRHSSVG 399
               :|:.| :..|.||                   ..|||:           .||.:.||...:.
Zfish   213 ---QRSST-VFVAKNGLERQPSQSETCFVRKDKFEKESPSS-----------NSSESAQRQEELD 262

  Fly   400 NTSLTYSTCGGLSSGGGALAG----HGSGGGVSGSTGLLGSPHHK----------KLRFQLAKEK 450
            :..|..|......:.|...:.    .|...|...|..:..:.|.:          |.:....:||
Zfish   263 DIDLEESAASDSRARGSRFSKRRRVEGERRGPQRSCRVSWAAHQEPGSRQQQLASKSKVAQMREK 327

  Fly   451 KASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRD 513
            :.:..|.::|..|.:||.|||....::..  |....|.:|..||.|:||.||.:|||||...|||
Zfish   328 RFTFVLAVVMGVFVLCWFPFFFTYSLQAVCGERCGPPEALFKLFFWIGYCNSSVNPIIYTIFNRD 392

  Fly   514 FRKPFQEIL 522
            |||.|::::
Zfish   393 FRKAFKKVV 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	133/389 (34%)
		TM helix 1	164..190	CDD:320452	13/25 (52%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	16/29 (55%)
		TM helix 4	277..299	CDD:320452	10/21 (48%)
		TM helix 5	319..348	CDD:320452	8/28 (29%)
		TM helix 6	447..477	CDD:320452	10/29 (34%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
adra2da	NP_919345.2	7tmA_alpha-2D_AR	44..397	CDD:320447	128/376 (34%)
		TM helix 2	65..91	CDD:320447	13/25 (52%)
		TM helix 3	103..133	CDD:320447	16/29 (55%)
		TM helix 4	145..168	CDD:320447	11/22 (50%)
		TM helix 5	181..210	CDD:320447	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..306		13/74 (18%)
		TM helix 6	324..354	CDD:320447	10/29 (34%)
		TM helix 7	365..390	CDD:320447	13/24 (54%)