Protein Alignment 5-HT7 and adra2b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_997521.2
• Gene: adra2b / 266751
• ZFINID: ZDB-GENE-021010-2
• Length: 509
• Species: Danio rerio
• Alignment Length: 524
• Identity: 153/524 - (29%)
• Similarity: 238/524 - (45%)
• Gaps: 146/524 - (27%)

  Fly   116 PIAIVSYQGITSSNLGDSNTT-------LVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVI 173
            |:| |...|.|:...|.|:.|       |.|.|                |..|:.|.:.:.|:::
Zfish     6 PVA-VGLPGHTNGTGGTSSPTCNQSMIKLAPYS----------------PEATAAFATAITLMML 53

  Fly   174 LGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIW 238
            : |:|||:||.|||...|.||.|.|..|||||.:|:.||.|::|.:|..|::..|.|..:.|:|:
Zfish    54 I-TIVGNILVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRSVWCEIY 117

  Fly   239 VSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG- 302
            ::.|||.||:||::|||||:|||::|::.:.||.||||:|:...:.:|||.:|.||.||||.:.
Zfish   118 LALDVLFCTSSIVHLCAISLDRYMSISRAVTYGPKRTPKRIKCAILVVWLISAVISFPPLLSMNK 182

  Fly   303 NEHEDEEGQ-PICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRI-------------- 352
            |:...|.|. |.|.:.....|.:|:|:|||:.|..:|:.||.:|::.|::.
Zfish   183 NKGGGESGALPQCQLNDERWYILYSTIGSFFAPCLIMILVYMRIYQIAKQRTRCPPGEPRKEAPA 247

  Fly   353 -------------------VLEEK-RAQT-------HLQQALNG--------------TGSPSAP 376
                               .|::| |..|       .:|||.|.              |.:...|
Zfish   248 NATTPQHKIQNGRGDETPGTLQKKARPPTLAVSQVESVQQAANTPIANNLLQAPSTTLTPTTPCP 312

  Fly   377 QAPPLGHTELASS------------------------GNGQRHSSVGNTSLTYSTCGGLSSGGGA 417
            ...|...:|:|.|                        .||:..||..:|          ..||..
Zfish   313 SPSPSNSSEVAPSKSKEGKKEKKKKNNKNKNKKEPDNNNGESMSSDSDT----------EQGGRG 367

  Fly   418 L----------AGHGSGGGVSGSTGLL----------------GSPHHKKLRFQLAKEKKASTTL 456
            |          :|..|...:.....::                |:|:..:.:..:.:||:.:..|
Zfish   368 LEVPCTPTMTPSGIHSPATMQKYRDMIATAKGAKLVARKAKQDGTPNSARRKAMVNREKRFTFVL 432

  Fly   457 GIIMSAFTVCWLPFFI---LALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPF 518
            .:::..|.:||.|||.   |..:.| |:..:|..|...|.|:||.||.|||:||...|:|||:.|
Zfish   433 AVVIGVFVICWFPFFFSYSLQAVCP-ESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAF 496

  Fly   519 QEIL 522
            ::||
Zfish   497 KKIL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	137/464 (30%)
		TM helix 1	164..190	CDD:320452	11/25 (44%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	9/21 (43%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	10/32 (31%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
adra2b	NP_997521.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..284		4/49 (8%)