Protein Alignment 5-HT7 and ser-6

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_741350.1
• Gene: ser-6 / 259560
• WormBaseID: WBGene00021897
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 417
• Identity: 112/417 - (26%)
• Similarity: 196/417 - (47%)
• Gaps: 78/417 - (18%)

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            |.:|:.|.:|....|:||:||...:...:.|:...|:|::||.:|||.:.:|::|.|::.|...:
 Worm     2 ILLSLTLGVVNCFVVIGNLLVFYVILTKKSLQTSTNHLVLSLTISDLLLGILILPFAIIQEHSNE 66

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |.||...|.:|:|.||...||||.||.|||.|||:|:.:|::|.:..:.:.:.|...:||..:..
 Worm    67 WIFGHFGCRLWLSVDVFLSTASIYNLLAISFDRYMAVRQPIKYPIISSTKVVRLMTFLVWFCSLL 131

  Fly   293 ISLPPLLILG-NEHEDEEGQPICTVCQNFA----YQIYATLGSFYIPLSVMLFVYYQIFR----A 348
            :::...::|. |.|:.|..:.    ||..:    |.|::.:.||.:|..||:.:..:||:    .
 Worm   132 LAVILFVLLTLNAHDSEPTKD----CQPTSLPSMYIIFSAMASFIVPAFVMVILNVRIFQTVLHT 192

  Fly   349 ARRIVLEEK--------------------RAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQ 393
            :|.:.::.|                    :.:|.|.......||||.....|:....:..    :
 Worm   193 SRTMTVKSKNGSLRVHRRKEPIIPVKKHDKYETRLSHEEECVGSPSKEVIDPIPVVAVVE----K 253

  Fly   394 RHSSVG------NTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLG----------------S 436
            .|.|..      .:.||::...|:..              :..|.::.                |
 Worm   254 HHKSSAVDAPAIRSFLTHTVVFGVLE--------------AKKTNIINHITQWWRRSTVRSPNPS 304

  Fly   437 PHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHV-----PASLSSLFLWLG 496
            ...|.:|..|..|.:.:.|.||:::||.|||:||..:.:::.:....|     ||||.:...|||
 Worm   305 TRKKCMRRSLRTEIRVARTTGIVVAAFIVCWIPFTTIYVLQAYAVCTVAAGCIPASLFTTAFWLG 369

  Fly   497 YANSLLNPIIYATLNRDFRKPFQEILY 523
            |:||.:|||:||..:||||...:.:.:
 Worm   370 YSNSAVNPILYAAFSRDFRIALKRLFF 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	112/410 (27%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	18/29 (62%)
		TM helix 4	277..299	CDD:320452	3/21 (14%)
		TM helix 5	319..348	CDD:320452	9/36 (25%)
		TM helix 6	447..477	CDD:320452	11/29 (38%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
ser-6	NP_741350.1	7tmA_amine_R-like	3..391	CDD:320098	111/409 (27%)
		TM helix 1	3..29	CDD:320098	8/25 (32%)
		TM helix 2	36..63	CDD:320098	10/26 (38%)
		TM helix 3	74..104	CDD:320098	18/29 (62%)
		TM helix 4	116..136	CDD:320098	3/19 (16%)
		TM helix 5	158..314	CDD:320098	27/173 (16%)
		TM helix 6	315..345	CDD:320098	11/29 (38%)
		TM helix 7	359..384	CDD:320098	14/24 (58%)